1fj4: Difference between revisions

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[[Image:1fj4.jpg|left|200px]]<br /><applet load="1fj4" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1fj4.jpg|left|200px]]
caption="1fj4, resolution 2.35&Aring;" />
 
'''THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH THIOLACTOMYCIN, IMPLICATIONS FOR DRUG DESIGN'''<br />
{{Structure
|PDB= 1fj4 |SIZE=350|CAPTION= <scene name='initialview01'>1fj4</scene>, resolution 2.35&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=TLM:THIOLACTOMYCIN'>TLM</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41]
|GENE=
}}
 
'''THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH THIOLACTOMYCIN, IMPLICATIONS FOR DRUG DESIGN'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1FJ4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=TLM:'>TLM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FJ4 OCA].  
1FJ4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FJ4 OCA].  


==Reference==
==Reference==
Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism., Price AC, Choi KH, Heath RJ, Li Z, White SW, Rock CO, J Biol Chem. 2001 Mar 2;276(9):6551-9. Epub 2000 Oct 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11050088 11050088]
Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism., Price AC, Choi KH, Heath RJ, Li Z, White SW, Rock CO, J Biol Chem. 2001 Mar 2;276(9):6551-9. Epub 2000 Oct 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11050088 11050088]
[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: White, S W.]]
[[Category: White, S W.]]
[[Category: TLM]]
[[Category: TLM]]
[[Category: condensing enzymes]]
[[Category: condensing enzyme]]
[[Category: drug design]]
[[Category: drug design]]
[[Category: fatty acid elongation]]
[[Category: fatty acid elongation]]
[[Category: thiolactomycin]]
[[Category: thiolactomycin]]


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