1t4v: Difference between revisions

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Revision as of 01:59, 27 July 2012

File:1t4v.png

Template:STRUCTURE 1t4v

Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin

Template:ABSTRACT PUBMED 15203151

About this Structure

1t4v is a 3 chain structure of Hirudin and Thrombin with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Lu T, Markotan T, Coppo F, Tomczuk B, Crysler C, Eisennagel S, Spurlino J, Gremminger L, Soll RM, Giardino EC, Bone R. Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3727-31. PMID:15203151 doi:https://dx.doi.org/10.1016/j.bmcl.2004.05.002

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