1gi9: Difference between revisions

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[[Image:1gi9.jpg|left|200px]]<br /><applet load="1gi9" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1gi9.jpg|left|200px]]
caption="1gi9, resolution 1.80&Aring;" />
 
'''A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE'''<br />
{{Structure
|PDB= 1gi9 |SIZE=350|CAPTION= <scene name='initialview01'>1gi9</scene>, resolution 1.80&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=123:2-(2-HYDROXY-5-METHOXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE'>123</scene> and <scene name='pdbligand=CIT:CITRIC ACID'>CIT</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73]
|GENE=
}}
 
'''A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1GI9 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=123:'>123</scene> and <scene name='pdbligand=CIT:'>CIT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GI9 OCA].  
1GI9 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GI9 OCA].  


==Reference==
==Reference==
A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site., Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W, J Mol Biol. 2001 Apr 13;307(5):1451-86. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11292354 11292354]
A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site., Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W, J Mol Biol. 2001 Apr 13;307(5):1451-86. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11292354 11292354]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: zn+2-mediated inhibition]]
[[Category: zn+2-mediated inhibition]]


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