1gkd: Difference between revisions

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[[Image:1gkd.gif|left|200px]]<br /><applet load="1gkd" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1gkd.gif|left|200px]]
caption="1gkd, resolution 2.10&Aring;" />
 
'''MMP9 ACTIVE SITE MUTANT-INHIBITOR COMPLEX'''<br />
{{Structure
|PDB= 1gkd |SIZE=350|CAPTION= <scene name='initialview01'>1gkd</scene>, resolution 2.10&Aring;
|SITE= <scene name='pdbsite=BUA:Zn+Binding+Site+For+Chain+B'>BUA</scene>
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=STN:2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOIC ACID'>STN</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Gelatinase_B Gelatinase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.35 3.4.24.35]
|GENE=
}}
 
'''MMP9 ACTIVE SITE MUTANT-INHIBITOR COMPLEX'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1GKD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=STN:'>STN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Gelatinase_B Gelatinase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.35 3.4.24.35] Known structural/functional Site: <scene name='pdbsite=BUA:Zn+Binding+Site+For+Chain+B'>BUA</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GKD OCA].  
1GKD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GKD OCA].  


==Reference==
==Reference==
Crystal structure of human MMP9 in complex with a reverse hydroxamate inhibitor., Rowsell S, Hawtin P, Minshull CA, Jepson H, Brockbank SM, Barratt DG, Slater AM, McPheat WL, Waterson D, Henney AM, Pauptit RA, J Mol Biol. 2002 May 24;319(1):173-81. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12051944 12051944]
Crystal structure of human MMP9 in complex with a reverse hydroxamate inhibitor., Rowsell S, Hawtin P, Minshull CA, Jepson H, Brockbank SM, Barratt DG, Slater AM, McPheat WL, Waterson D, Henney AM, Pauptit RA, J Mol Biol. 2002 May 24;319(1):173-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12051944 12051944]
[[Category: Gelatinase B]]
[[Category: Gelatinase B]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: matrix metalloprotease]]
[[Category: matrix metalloprotease]]


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