1go5: Difference between revisions
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[[Image:1go5.jpg|left|200px]] | [[Image:1go5.jpg|left|200px]] | ||
'''STRUCTURE OF THE C-TERMINAL FG-BINDING DOMAIN OF HUMAN TAP''' | {{Structure | ||
|PDB= 1go5 |SIZE=350|CAPTION= <scene name='initialview01'>1go5</scene> | |||
|SITE= | |||
|LIGAND= | |||
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'''STRUCTURE OF THE C-TERMINAL FG-BINDING DOMAIN OF HUMAN TAP''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1GO5 is a [ | 1GO5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GO5 OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1., Grant RP, Hurt E, Neuhaus D, Stewart M, Nat Struct Biol. 2002 Apr;9(4):247-51. PMID:[http:// | Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1., Grant RP, Hurt E, Neuhaus D, Stewart M, Nat Struct Biol. 2002 Apr;9(4):247-51. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11875519 11875519] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: mrna export]] | [[Category: mrna export]] | ||
[[Category: nuclear transport]] | [[Category: nuclear transport]] | ||
[[Category: | [[Category: nucleoporin]] | ||
[[Category: uba]] | [[Category: uba]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:25:47 2008'' | ||
Revision as of 09:25, 20 March 2008
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STRUCTURE OF THE C-TERMINAL FG-BINDING DOMAIN OF HUMAN TAP
Overview
The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling. We report the solution structure of this C-terminal domain, which is based on a distinctive arrangement of four alpha-helices and is joined to the next module by a flexible 12-residue Pro-rich linker. F617A Tap suppresses FG-nucleoporin binding by the most C-terminal domain that, together with the structure of the other modules from which Tap is constructed, provides a structural context for its nuclear shuttling function.
Disease
Known diseases associated with this structure: Bare lymphocyte syndrome, type I OMIM:[170260]
About this Structure
1GO5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1., Grant RP, Hurt E, Neuhaus D, Stewart M, Nat Struct Biol. 2002 Apr;9(4):247-51. PMID:11875519
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