1gth: Difference between revisions

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[[Image:1gth.gif|left|200px]]<br /><applet load="1gth" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1gth.gif|left|200px]]
caption="1gth, resolution 2.25&Aring;" />
 
'''DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, TERNARY COMPLEX WITH NADPH AND 5-IODOURACIL'''<br />
{{Structure
|PDB= 1gth |SIZE=350|CAPTION= <scene name='initialview01'>1gth</scene>, resolution 2.25&Aring;
|SITE= <scene name='pdbsite=FA1:Ura+Binding+Site+For+Chain+D'>FA1</scene>
|LIGAND= <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=IDH:(5S)-5-IODODIHYDRO-2,4(1H,3H)-PYRIMIDINEDIONE'>IDH</scene>, <scene name='pdbligand=IUR:5-IODOURACIL'>IUR</scene> and <scene name='pdbligand=URA:URACIL'>URA</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydropyrimidine_dehydrogenase_(NADP(+)) Dihydropyrimidine dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.2 1.3.1.2]
|GENE=
}}
 
'''DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, TERNARY COMPLEX WITH NADPH AND 5-IODOURACIL'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1GTH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with <scene name='pdbligand=SF4:'>SF4</scene>, <scene name='pdbligand=FMN:'>FMN</scene>, <scene name='pdbligand=FAD:'>FAD</scene>, <scene name='pdbligand=NDP:'>NDP</scene>, <scene name='pdbligand=IDH:'>IDH</scene>, <scene name='pdbligand=IUR:'>IUR</scene> and <scene name='pdbligand=URA:'>URA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dihydropyrimidine_dehydrogenase_(NADP(+)) Dihydropyrimidine dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.2 1.3.1.2] Known structural/functional Site: <scene name='pdbsite=FA1:Ura+Binding+Site+For+Chain+D'>FA1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GTH OCA].  
1GTH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GTH OCA].  


==Reference==
==Reference==
Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer., Dobritzsch D, Ricagno S, Schneider G, Schnackerz KD, Lindqvist Y, J Biol Chem. 2002 Apr 12;277(15):13155-66. Epub 2002 Jan 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11796730 11796730]
Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer., Dobritzsch D, Ricagno S, Schneider G, Schnackerz KD, Lindqvist Y, J Biol Chem. 2002 Apr 12;277(15):13155-66. Epub 2002 Jan 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11796730 11796730]
[[Category: Dihydropyrimidine dehydrogenase (NADP(+))]]
[[Category: Dihydropyrimidine dehydrogenase (NADP(+))]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: electron transfer]]
[[Category: electron transfer]]
[[Category: flavin]]
[[Category: flavin]]
[[Category: iron-sulfur clusters]]
[[Category: iron-sulfur cluster]]
[[Category: oxidoreductase]]
[[Category: oxidoreductase]]
[[Category: pyrimidine catabolism]]
[[Category: pyrimidine catabolism]]


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