1h4t: Difference between revisions

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[[Image:1h4t.gif|left|200px]]<br /><applet load="1h4t" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1h4t.gif|left|200px]]
caption="1h4t, resolution 2.9&Aring;" />
 
'''PROLYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH L-PROLINE'''<br />
{{Structure
|PDB= 1h4t |SIZE=350|CAPTION= <scene name='initialview01'>1h4t</scene>, resolution 2.9&Aring;
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Chain+B'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Chain+C'>AC3</scene>, <scene name='pdbsite=AC4:Zn+Binding+Site+For+Chain+D'>AC4</scene>, <scene name='pdbsite=AC5:PRO+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:PRO+Binding+Site+For+Chain+B'>AC6</scene>, <scene name='pdbsite=AC7:PRO+Binding+Site+For+Chain+C'>AC7</scene> and <scene name='pdbsite=AC8:PRO+Binding+Site+For+Chain+D'>AC8</scene>
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=PRO:PROLINE'>PRO</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15]
|GENE=
}}
 
'''PROLYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH L-PROLINE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1H4T is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=PRO:'>PRO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] Known structural/functional Sites: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Chain+B'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Chain+C'>AC3</scene>, <scene name='pdbsite=AC4:Zn+Binding+Site+For+Chain+D'>AC4</scene>, <scene name='pdbsite=AC5:PRO+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:PRO+Binding+Site+For+Chain+B'>AC6</scene>, <scene name='pdbsite=AC7:PRO+Binding+Site+For+Chain+C'>AC7</scene> and <scene name='pdbsite=AC8:PRO+Binding+Site+For+Chain+D'>AC8</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H4T OCA].  
1H4T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H4T OCA].  


==Reference==
==Reference==
A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase., Yaremchuk A, Tukalo M, Grotli M, Cusack S, J Mol Biol. 2001 Jun 15;309(4):989-1002. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11399074 11399074]
A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase., Yaremchuk A, Tukalo M, Grotli M, Cusack S, J Mol Biol. 2001 Jun 15;309(4):989-1002. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11399074 11399074]
[[Category: Proline--tRNA ligase]]
[[Category: Proline--tRNA ligase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: class ii aminoacyl-trna synthetase]]
[[Category: class ii aminoacyl-trna synthetase]]


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