3frz: Difference between revisions
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Revision as of 11:51, 27 July 2012
Crystal Structure of HCV NS5B RNA polymerase in complex with PF868554
Template:ABSTRACT PUBMED 19209845
About this Structure
3frz is a 1 chain structure of RNA polymerase with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
See Also
Reference
- Li H, Tatlock J, Linton A, Gonzalez J, Jewell T, Patel L, Ludlum S, Drowns M, Rahavendran SV, Skor H, Hunter R, Shi ST, Herlihy KJ, Parge H, Hickey M, Yu X, Chau F, Nonomiya J, Lewis C. Discovery of (R)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1 ,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-on e (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor. J Med Chem. 2009 Feb 11. PMID:19209845 doi:10.1021/jm8014537
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Categories:
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- Hepatitis c virus
- RNA-directed RNA polymerase
- Parge, H E.
- Apoptosis
- Atp-binding
- Capsid protein
- Cell membrane
- Endoplasmic reticulum
- Envelope protein
- Fusion protein
- Glycoprotein
- Helicase
- Host-virus interaction
- Hydrolase
- Interferon antiviral system evasion
- Lipid droplet
- Lipoprotein
- Membrane
- Metal-binding
- Mitochondrion
- Multifunctional enzyme
- Nucleotide-binding
- Nucleotidyltransferase
- Nucleus
- Oncogene
- Palmitate
- Phosphoprotein
- Protease
- Ribonucleoprotein
- Rna replication
- Rna-binding
- Rna-directed rna polymerase
- Secreted
- Serine protease
- Sh3-binding
- Thiol protease
- Transcription
- Transcription regulation
- Transferase
- Transmembrane
- Viral nucleoprotein
- Viral polymerase
- Virion
