1h8b: Difference between revisions
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'''EF-HANDS 3,4 FROM ALPHA-ACTININ / Z-REPEAT 7 FROM TITIN''' | {{Structure | ||
|PDB= 1h8b |SIZE=350|CAPTION= <scene name='initialview01'>1h8b</scene> | |||
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|LIGAND= | |||
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'''EF-HANDS 3,4 FROM ALPHA-ACTININ / Z-REPEAT 7 FROM TITIN''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1H8B is a [ | 1H8B is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8B OCA]. | ||
==Reference== | ==Reference== | ||
Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex., Atkinson RA, Joseph C, Kelly G, Muskett FW, Frenkiel TA, Nietlispach D, Pastore A, Nat Struct Biol. 2001 Oct;8(10):853-7. PMID:[http:// | Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex., Atkinson RA, Joseph C, Kelly G, Muskett FW, Frenkiel TA, Nietlispach D, Pastore A, Nat Struct Biol. 2001 Oct;8(10):853-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11573089 11573089] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
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[[Category: z-disk structural complex]] | [[Category: z-disk structural complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:33:38 2008'' | ||
Revision as of 09:33, 20 March 2008
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EF-HANDS 3,4 FROM ALPHA-ACTININ / Z-REPEAT 7 FROM TITIN
Overview
The interaction between alpha-actinin and titin, two modular muscle proteins, is essential for sarcomere assembly. We have solved the solution structure of a complex between the calcium-insensitive C-terminal EF-hand domain of alpha-actinin-2 and the seventh Z-repeat of titin. The structure of the complex is in a semi-open conformation and closely resembles that of myosin light chains in their complexes with heavy chain IQ motifs. However, no IQ motif is present in the Z-repeat, suggesting that the semi-open conformation is a general structural solution for calcium-independent recognition of EF-hand domains.
About this Structure
1H8B is a Protein complex structure of sequences from Homo sapiens and Oryctolagus cuniculus. Full crystallographic information is available from OCA.
Reference
Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex., Atkinson RA, Joseph C, Kelly G, Muskett FW, Frenkiel TA, Nietlispach D, Pastore A, Nat Struct Biol. 2001 Oct;8(10):853-7. PMID:11573089
Page seeded by OCA on Thu Mar 20 11:33:38 2008
