1hbv: Difference between revisions

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[[Image:1hbv.gif|left|200px]]<br /><applet load="1hbv" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1hbv.gif|left|200px]]
caption="1hbv, resolution 2.3&Aring;" />
 
'''A CHECK ON RATIONAL DRUG DESIGN. CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A NOVEL GAMMA-TURN MIMETIC'''<br />
{{Structure
|PDB= 1hbv |SIZE=350|CAPTION= <scene name='initialview01'>1hbv</scene>, resolution 2.3&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=GAN:2-[3-BENZYL-5-(1-ALANYL-AMINOETHYL)-2,3,6,7-TETRAHYDRO-1H-AZEPIN-1-YL]-1-OXOPROPYL-VALINYL-VALINE-METHYLESTER'>GAN</scene>
|ACTIVITY=
|GENE= HIV-1 PROTEASE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''A CHECK ON RATIONAL DRUG DESIGN. CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A NOVEL GAMMA-TURN MIMETIC'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1HBV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=GAN:'>GAN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1HBV with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb29_1.html Penicillin-binding Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HBV OCA].  
1HBV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. The following page contains interesting information on the relation of 1HBV with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb29_1.html Penicillin-binding Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HBV OCA].  


==Reference==
==Reference==
A check on rational drug design: crystal structure of a complex of human immunodeficiency virus type 1 protease with a novel gamma-turn mimetic inhibitor., Hoog SS, Zhao B, Winborne E, Fisher S, Green DW, DesJarlais RL, Newlander KA, Callahan JF, Moore ML, Huffman WF, et al., J Med Chem. 1995 Aug 18;38(17):3246-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7650677 7650677]
A check on rational drug design: crystal structure of a complex of human immunodeficiency virus type 1 protease with a novel gamma-turn mimetic inhibitor., Hoog SS, Zhao B, Winborne E, Fisher S, Green DW, DesJarlais RL, Newlander KA, Callahan JF, Moore ML, Huffman WF, et al., J Med Chem. 1995 Aug 18;38(17):3246-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7650677 7650677]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Penicillin-binding Proteins]]
[[Category: Penicillin-binding Proteins]]
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[[Category: hydrolase (acid protease)]]
[[Category: hydrolase (acid protease)]]


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