1hdc: Difference between revisions

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[[Image:1hdc.jpg|left|200px]]~~<br /><applet load~~="1hdc~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1hdc.jpg|left|200px]]

~~caption="~~1hdc, resolution 2.20Å" />

'''MECHANISM OF INHIBITION OF 3ALPHA,20BETA-HYDROXYSTEROID DEHYDROGENASE BY A LICORICE-DERIVED STEROIDAL INHIBITOR'''~~<br />~~

{{Structure

|PDB= 1hdc |SIZE=350|CAPTION= <scene name='initialview01'>1hdc</scene>, resolution 2.20Å

|SITE=

|LIGAND= <scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/3-alpha-(or_20-beta)-hydroxysteroid_dehydrogenase 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.53 1.1.1.53]

|GENE=

}}

'''MECHANISM OF INHIBITION OF 3ALPHA,20BETA-HYDROXYSTEROID DEHYDROGENASE BY A LICORICE-DERIVED STEROIDAL INHIBITOR'''

==Overview==

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==About this Structure==

1HDC is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_exfoliatus Streptomyces exfoliatus] ~~with <scene name='pdbligand=CBO:'>CBO</scene> as [http://en.wikipedia~~.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/3-alpha-(or_20-beta)-hydroxysteroid_dehydrogenase 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.53 1.1.1.53] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HDC OCA].

1HDC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_exfoliatus Streptomyces exfoliatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HDC OCA].

==Reference==

Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor., Ghosh D, Erman M, Wawrzak Z, Duax WL, Pangborn W, Structure. 1994 Oct 15;2(10):973-80. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~7866748 7866748]

Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor., Ghosh D, Erman M, Wawrzak Z, Duax WL, Pangborn W, Structure. 1994 Oct 15;2(10):973-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7866748 7866748]

[[Category: 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase]]

[[Category: Single protein]]

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[[Category: oxidoreductase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 13~~:00:07 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:35:40 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1hdc.jpg|left|200px]]<br /><applet load="1hdc" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1hdc.jpg|left|200px]]
-caption="1hdc, resolution 2.20&Aring;" />
-'''MECHANISM OF INHIBITION OF 3ALPHA,20BETA-HYDROXYSTEROID DEHYDROGENASE BY A LICORICE-DERIVED STEROIDAL INHIBITOR'''<br />
+ {{Structure
+|PDB= 1hdc |SIZE=350|CAPTION= <scene name='initialview01'>1hdc</scene>, resolution 2.20&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/3-alpha-(or_20-beta)-hydroxysteroid_dehydrogenase 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.53 1.1.1.53]
+|GENE=
+}}
+'''MECHANISM OF INHIBITION OF 3ALPHA,20BETA-HYDROXYSTEROID DEHYDROGENASE BY A LICORICE-DERIVED STEROIDAL INHIBITOR'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-HDC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_exfoliatus Streptomyces exfoliatus] with <scene name='pdbligand=CBO:'>CBO</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/3-alpha-(or_20-beta)-hydroxysteroid_dehydrogenase 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.53 1.1.1.53] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HDC OCA].
+HDC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_exfoliatus Streptomyces exfoliatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HDC OCA].
 ==Reference==
-Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor., Ghosh D, Erman M, Wawrzak Z, Duax WL, Pangborn W, Structure. 1994 Oct 15;2(10):973-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7866748 7866748]
+Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor., Ghosh D, Erman M, Wawrzak Z, Duax WL, Pangborn W, Structure. 1994 Oct 15;2(10):973-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7866748 7866748]
 [[Category: 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase]]
 [[Category: Single protein]]
@@ Line 18: / Line 27: @@
 [[Category: oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:00:07 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:35:40 2008''