1hjf: Difference between revisions

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[[Image:1hjf.gif|left|200px]]<br /><applet load="1hjf" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1hjf.gif|left|200px]]
caption="1hjf, resolution 1.60&Aring;" />
 
'''ALTERATION OF THE CO-SUBSTRATE SELECTIVITY OF DEACETOXYCEPHALOSPORIN C SYNTHASE: THE ROLE OF ARGININE-258'''<br />
{{Structure
|PDB= 1hjf |SIZE=350|CAPTION= <scene name='initialview01'>1hjf</scene>, resolution 1.60&Aring;
|SITE= <scene name='pdbsite=COI:Coi+Binding+Site+For+Chain+A'>COI</scene> and <scene name='pdbsite=FE:Protein+Fe-Binding+Ligands.+2-Oxo-4-Methylpentanoate+Cos+...'>FE</scene>
|LIGAND= <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene> and <scene name='pdbligand=COI:2-OXO-4-METHYLPENTANOIC ACID'>COI</scene>
|ACTIVITY=
|GENE= CEFE, R258Q MUTANT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1901 Streptomyces clavuligerus])
}}
 
'''ALTERATION OF THE CO-SUBSTRATE SELECTIVITY OF DEACETOXYCEPHALOSPORIN C SYNTHASE: THE ROLE OF ARGININE-258'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1HJF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_clavuligerus Streptomyces clavuligerus] with <scene name='pdbligand=FE2:'>FE2</scene> and <scene name='pdbligand=COI:'>COI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=COI:Coi+Binding+Site+For+Chain+A'>COI</scene> and <scene name='pdbsite=FE:Protein+Fe-Binding+Ligands.+2-Oxo-4-Methylpentanoate+Cos+...'>FE</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJF OCA].  
1HJF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_clavuligerus Streptomyces clavuligerus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJF OCA].  


==Reference==
==Reference==
Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase. The role of arginine 258., Lee HJ, Lloyd MD, Clifton IJ, Harlos K, Dubus A, Baldwin JE, Frere JM, Schofield CJ, J Biol Chem. 2001 May 25;276(21):18290-5. Epub 2001 Feb 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11279000 11279000]
Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase. The role of arginine 258., Lee HJ, Lloyd MD, Clifton IJ, Harlos K, Dubus A, Baldwin JE, Frere JM, Schofield CJ, J Biol Chem. 2001 May 25;276(21):18290-5. Epub 2001 Feb 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11279000 11279000]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Streptomyces clavuligerus]]
[[Category: Streptomyces clavuligerus]]
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[[Category: FE2]]
[[Category: FE2]]
[[Category: 2-oxoglutarate-dependent oxygenase]]
[[Category: 2-oxoglutarate-dependent oxygenase]]
[[Category: alternative 2-oxoacids]]
[[Category: alternative 2-oxoacid]]
[[Category: cephem antibiotic biosynthesis]]
[[Category: cephem antibiotic biosynthesis]]
[[Category: chemical cosubstrate rescue]]
[[Category: chemical cosubstrate rescue]]
[[Category: co-substrate selectivity]]
[[Category: co-substrate selectivity]]


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