1hle: Difference between revisions
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[[Image:1hle.jpg|left|200px]] | [[Image:1hle.jpg|left|200px]] | ||
'''CRYSTAL STRUCTURE OF CLEAVED EQUINE LEUCOCYTE ELASTASE INHIBITOR DETERMINED AT 1.95 ANGSTROMS RESOLUTION''' | {{Structure | ||
|PDB= 1hle |SIZE=350|CAPTION= <scene name='initialview01'>1hle</scene>, resolution 1.95Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=ACE:ACETYL GROUP'>ACE</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''CRYSTAL STRUCTURE OF CLEAVED EQUINE LEUCOCYTE ELASTASE INHIBITOR DETERMINED AT 1.95 ANGSTROMS RESOLUTION''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1HLE is a [ | 1HLE is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLE OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution., Baumann U, Bode W, Huber R, Travis J, Potempa J, J Mol Biol. 1992 Aug 20;226(4):1207-18. PMID:[http:// | Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution., Baumann U, Bode W, Huber R, Travis J, Potempa J, J Mol Biol. 1992 Aug 20;226(4):1207-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1518052 1518052] | ||
[[Category: Equus caballus]] | [[Category: Equus caballus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: hydrolase inhibitor(serine proteinase)]] | [[Category: hydrolase inhibitor(serine proteinase)]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:38:41 2008'' | ||
Revision as of 09:38, 20 March 2008
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| 1hle, resolution 1.95Å | |||||||||||||
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| Ligands: | CA and ACE | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
CRYSTAL STRUCTURE OF CLEAVED EQUINE LEUCOCYTE ELASTASE INHIBITOR DETERMINED AT 1.95 ANGSTROMS RESOLUTION
Overview
The crystal structure of active-site cleaved equine leucocyte elastase inhibitor, a member of the serpin superfamily, has been solved and refined to a crystallographic R-factor of 17.6% at 1.95 A resolution. Despite being an intracellular inhibitor with rather low sequence homology of 30% to human alpha 1-antichymotrypsin and alpha 1-proteinase inhibitor, the three-dimensional structures are very similar, with deviations only at the sites of insertions and few mobile secondary structure elements. The better resolution in comparison with the structures of other cleaved serpins allows a more precise description of the so-called R-state of the serpins.
About this Structure
1HLE is a Protein complex structure of sequences from Equus caballus. Full crystallographic information is available from OCA.
Reference
Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution., Baumann U, Bode W, Huber R, Travis J, Potempa J, J Mol Biol. 1992 Aug 20;226(4):1207-18. PMID:1518052
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