4fxf: Difference between revisions
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{{STRUCTURE_4fxf| PDB=4fxf | SCENE= }} | |||
===Structure of M2 pyruvate kinase in complex with phenylalanine=== | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN]] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref><ref>PMID:18191611</ref><ref>PMID:21620138</ref> | |||
==About this Structure== | |||
[[4fxf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXF OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Pyruvate kinase]] | |||
[[Category: Morgan, H P.]] | |||
[[Category: Walkinshaw, M D.]] | |||
[[Category: Atp binding]] | |||
[[Category: Tim barrel]] | |||
[[Category: Transferase]] | |||
