1hzw: Difference between revisions

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[[Image:1hzw.gif|left|200px]]<br /><applet load="1hzw" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1hzw.gif|left|200px]]
caption="1hzw, resolution 2.0&Aring;" />
 
'''CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE'''<br />
{{Structure
|PDB= 1hzw |SIZE=350|CAPTION= <scene name='initialview01'>1hzw</scene>, resolution 2.0&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE'''
 


==Overview==
==Overview==
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==Disease==
==Disease==
Known disease associated with this structure: Timothy syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=114205 114205]]
Known diseases associated with this structure: Brugada syndrome 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=114205 114205]], Timothy syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=114205 114205]]


==About this Structure==
==About this Structure==
1HZW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZW OCA].  
1HZW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZW OCA].  


==Reference==
==Reference==
Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP., Almog R, Waddling CA, Maley F, Maley GF, Van Roey P, Protein Sci. 2001 May;10(5):988-96. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11316879 11316879]
Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP., Almog R, Waddling CA, Maley F, Maley GF, Van Roey P, Protein Sci. 2001 May;10(5):988-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11316879 11316879]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: uncomplexed]]
[[Category: uncomplexed]]


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