2lu4: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Solution NMR structure of the beta2 carbohydrate module of AMP-activated protein kinase bound to glucosyl-cyclodextrin===

~~The entry 2lu4 is ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/AAKB2_RAT AAKB2_RAT]] Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity).

~~Authors~~: Gooley, P., Koay, A., Stapleton, D.

==About this Structure==

[[2lu4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU4 OCA].

~~Description~~: ~~Solution NMR structure of the beta2 carbohydrate module of AMP-activated~~ protein ~~kinase bound to glucosyl-cyclodextrin~~

[[Category: Rattus norvegicus]]

[[Category: Gooley, P.]]

[[Category: Koay, A.]]

[[Category: Stapleton, D.]]

[[Category: Carbohydrate binding module]]

[[Category: Glycogen binding]]

[[Category: Sugar binding protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_2lu4|  PDB=2lu4  |  SCENE=  }}
+===Solution NMR structure of the beta2 carbohydrate module of AMP-activated protein kinase bound to glucosyl-cyclodextrin===
-The entry 2lu4 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/AAKB2_RAT AAKB2_RAT]] Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity).
-Authors: Gooley, P., Koay, A., Stapleton, D.
+==About this Structure==
+[[2lu4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU4 OCA].
-Description: Solution NMR structure of the beta2 carbohydrate module of AMP-activated protein kinase bound to glucosyl-cyclodextrin
+[[Category: Rattus norvegicus]]
+[[Category: Gooley, P.]]
+[[Category: Koay, A.]]
+[[Category: Stapleton, D.]]
+[[Category: Carbohydrate binding module]]
+[[Category: Glycogen binding]]
+[[Category: Sugar binding protein]]