1pnn: Difference between revisions
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[[ | ==PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA== | ||
<StructureSection load='1pnn' size='340' side='right' caption='[[1pnn]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1pnn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PNN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PNN FirstGlance]. <br> | |||
</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-CYTOSINE'>CPN</scene>, <scene name='pdbligand=IPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-5-IODOURACIL'>IPN</scene>, <scene name='pdbligand=TPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-THYMINE'>TPN</scene></td></tr> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pnn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pnn RCSB], [http://www.ebi.ac.uk/pdbsum/1pnn PDBsum]</span></td></tr> | |||
<table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The crystal structure of a nucleic acid triplex reveals a helix, designated P-form, that differs from previously reported nucleic acid structures. The triplex consists of one polypurine DNA strand complexed to a polypyrimidine hairpin peptide nucleic acid (PNA) and was successfully designed to promote Watson-Crick and Hoogsteen base pairing. The P-form helix is underwound, with a base tilt similar to B-form DNA. The bases are displaced from the helix axis even more than in A-form DNA. Hydrogen bonds between the DNA backbone and the Hoogsteen PNA backbone explain the observation that polypyrimidine PNA sequences form highly stable 2:1 PNA-DNA complexes. This structure expands the number of known stable helical forms that nucleic acids can adopt. | |||
A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex.,Betts L, Josey JA, Veal JM, Jordan SR Science. 1995 Dec 15;270(5243):1838-41. PMID:8525381<ref>PMID:8525381</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
< | |||
[[Category: Betts, L.]] | [[Category: Betts, L.]] | ||
[[Category: Veal, J M.]] | [[Category: Veal, J M.]] | ||
Revision as of 06:51, 9 June 2014
PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA
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