OspA L03 Group2: Difference between revisions

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[[Image:~~Bulls_eye~~.jpg|thumb|300px|alt=text|''~~Erythema migrans, as known as Bulls Eye Wound~~'']]

[[Image:picture_of_borellia.jpg|thumb|300px|alt=text|''Borrelia Burgdorferi'']

Outer surface protein A, or OspA is found to inhibit bacterial transmission <ref name=Ding >PMID: 11183781</ref>. Outer surface protein A, or OspA was found to initiate an immune response that contributed towards the development of Lyme disease vaccinations. It prevented the transmission of Borrelia burgdorferi, the causative bacterial agent of Lyme disease after the attachment of an infected tick <ref name=Ding >PMID: 11183781</ref>. Once entered the host through the skin or blood stream, Borrelia burgdorferi downregulated and suppressed OspA to minimize all of the host’s immunogenic characteristics <ref name=Ruprecht >PMID: 18097481</ref>. When OspA on the spirochete migrated to an inflammatory environment, it induced apoptosis on the bacteria through the activation of B-cells <ref name=Ruprecht >PMID: 18097481</ref>. Only OspA positive in borrelia bacteria were unable to establish an infection compared to OspA negative bacteria successfully hosted in studies of mice <ref name=Ruprecht >PMID: 18097481</ref>. OspA known as a potent stimulator of neutrophils was able to kill the pathogen and attract leukocytes allowing the release of proinflammatory cytokines in a host <ref name=Ruprecht >PMID: 18097481</ref> and avoid contracting Lyme disease as it affects the heart, joints, and nervous system <ref name=Ruprecht >PMID: 18097481</ref>.

OspA L03 Group2: Difference between revisions

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Revision as of 15:26, 14 August 2012 view source Chris DiFiore (talk \| contribs) 41 edits No edit summary ← Older edit		Revision as of 15:27, 14 August 2012 view source Kareema Roushdy (talk \| contribs) 36 edits No edit summary Newer edit →
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	[[Image:~~Bulls_eye~~.jpg\|thumb\|300px\|alt=text\|''~~Erythema migrans, as known as Bulls Eye Wound~~'']]		[[Image:picture_of_borellia.jpg\|thumb\|300px\|alt=text\|''Borrelia Burgdorferi'']


	Outer surface protein A, or OspA is found to inhibit bacterial transmission <ref name=Ding >PMID: 11183781</ref>. Outer surface protein A, or OspA was found to initiate an immune response that contributed towards the development of Lyme disease vaccinations. It prevented the transmission of Borrelia burgdorferi, the causative bacterial agent of Lyme disease after the attachment of an infected tick <ref name=Ding >PMID: 11183781</ref>. Once entered the host through the skin or blood stream, Borrelia burgdorferi downregulated and suppressed OspA to minimize all of the host’s immunogenic characteristics <ref name=Ruprecht >PMID: 18097481</ref>. When OspA on the spirochete migrated to an inflammatory environment, it induced apoptosis on the bacteria through the activation of B-cells <ref name=Ruprecht >PMID: 18097481</ref>. Only OspA positive in borrelia bacteria were unable to establish an infection compared to OspA negative bacteria successfully hosted in studies of mice <ref name=Ruprecht >PMID: 18097481</ref>. OspA known as a potent stimulator of neutrophils was able to kill the pathogen and attract leukocytes allowing the release of proinflammatory cytokines in a host <ref name=Ruprecht >PMID: 18097481</ref> and avoid contracting Lyme disease as it affects the heart, joints, and nervous system <ref name=Ruprecht >PMID: 18097481</ref>.		Outer surface protein A, or OspA is found to inhibit bacterial transmission <ref name=Ding >PMID: 11183781</ref>. Outer surface protein A, or OspA was found to initiate an immune response that contributed towards the development of Lyme disease vaccinations. It prevented the transmission of Borrelia burgdorferi, the causative bacterial agent of Lyme disease after the attachment of an infected tick <ref name=Ding >PMID: 11183781</ref>. Once entered the host through the skin or blood stream, Borrelia burgdorferi downregulated and suppressed OspA to minimize all of the host’s immunogenic characteristics <ref name=Ruprecht >PMID: 18097481</ref>. When OspA on the spirochete migrated to an inflammatory environment, it induced apoptosis on the bacteria through the activation of B-cells <ref name=Ruprecht >PMID: 18097481</ref>. Only OspA positive in borrelia bacteria were unable to establish an infection compared to OspA negative bacteria successfully hosted in studies of mice <ref name=Ruprecht >PMID: 18097481</ref>. OspA known as a potent stimulator of neutrophils was able to kill the pathogen and attract leukocytes allowing the release of proinflammatory cytokines in a host <ref name=Ruprecht >PMID: 18097481</ref> and avoid contracting Lyme disease as it affects the heart, joints, and nervous system <ref name=Ruprecht >PMID: 18097481</ref>.