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[[Image:208d.png|left|200px]]
==HIGH-RESOLUTION STRUCTURE OF A DNA HELIX FORMING (C.G)*G BASE TRIPLETS==
<StructureSection load='208d' size='340' side='right' caption='[[208d]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[208d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=208D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=208D FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=208d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=208d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=208d RCSB], [http://www.ebi.ac.uk/pdbsum/208d PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Triple helices result from interaction between single- and double-stranded nucleic acids. Their formation is a possible mechanism for recombination of homologous gene sequences in nature and provides, inter alia, a basis for artificial control of gene activity. Triple-helix motifs have been extensively studied by a variety of techniques, but few high-resolution structural data are available. The only triplet structures characterized so far by X-ray diffraction were in protein-DNA complexes studied at about 3 A resolution. We report here the X-ray analysis of a DNA nonamer, d(GCGAATTCG), to a resolution of 2.05 A, in which the extended crystal structure contains (C.G)*G triplets as a fragment of triple helix. The guanosine-containing chains are in a parallel orientation. This arrangement is a necessary feature of models for homologous recombination which results ultimately in replacement of one length of DNA by another of similar sequence. The present-structure agrees with many published predictions of triplex organization, and provides an accurate representation of an element that allows sequence-specific association between single- and double-stranded nucleic acids.


{{STRUCTURE_208d|  PDB=208d  |  SCENE=  }}
High-resolution structure of a DNA helix forming (C.G)*G base triplets.,Van Meervelt L, Vlieghe D, Dautant A, Gallois B, Precigoux G, Kennard O Nature. 1995 Apr 20;374(6524):742-4. PMID:7715732<ref>PMID:7715732</ref>


===HIGH-RESOLUTION STRUCTURE OF A DNA HELIX FORMING (C.G)*G BASE TRIPLETS===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_7715732}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[208d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=208D OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:007715732</ref><references group="xtra"/>
[[Category: Dautant, A.]]
[[Category: Dautant, A.]]
[[Category: Gallois, B.]]
[[Category: Gallois, B.]]
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