2oyw: Difference between revisions

Line 1:

[[~~Image~~:~~2oyw~~.~~png~~|~~left~~|~~200px~~]]

==Neurotensin in TFE:H2O (80:20)==

== Structural highlights ==

<table><tr><td colspan='2'>[[2oyw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OYW FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>

<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2oyv|2oyv]]</td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oyw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oyw RCSB], [http://www.ebi.ac.uk/pdbsum/2oyw PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

Neurotensin (NT) is a 13-residue neuropeptide that exerts multiple biological functions in the central and peripheral nervous system. Little is known about the structure of this neuropeptide, and what is known only concerns its C-terminal part. We determined here for the first time the structure of the full-length NT in membrane-mimicking environments by means of classical proton-proton distance constraints derived from solution-state NMR spectroscopy. NT was found to have a structure at both its N and C termini, whereas the central region of NT remains highly flexible. In TFE and HFIP solutions, the NT C-terminus presents an extended slightly incurved structure, whereas in DPC it has a beta turn. The N-terminal region of NT possesses great adaptability and accessibility to the microenvironment in the three media studied. Altogether, our work demonstrates a structure of NT fully compatible with its NTR-bound state.

~~{{STRUCTURE_2oyw| PDB=2oyw | SCENE= }}~~

NMR solution structure of neurotensin in membrane-mimetic environments: molecular basis for neurotensin receptor recognition.,Coutant J, Curmi PA, Toma F, Monti JP Biochemistry. 2007 May 15;46(19):5656-63. Epub 2007 Apr 19. PMID:17441729<ref>PMID:17441729</ref>

~~===Neurotensin in TFE:H2O (80:20)===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_17441729}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[2oyw]] is~~ a ~~1 chain structure. Full experimental information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2OYW OCA].~~

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:017441729<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Coutant, J.]]

[[Category: Curmi, P A.]]

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@@ Line 1: / Line 1: @@
-[[Image:2oyw.png|left|200px]]
+==Neurotensin in TFE:H2O (80:20)==
+<StructureSection load='2oyw' size='340' side='right' caption='[[2oyw]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2oyw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OYW FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2oyv|2oyv]]</td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oyw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oyw RCSB], [http://www.ebi.ac.uk/pdbsum/2oyw PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Neurotensin (NT) is a 13-residue neuropeptide that exerts multiple biological functions in the central and peripheral nervous system. Little is known about the structure of this neuropeptide, and what is known only concerns its C-terminal part. We determined here for the first time the structure of the full-length NT in membrane-mimicking environments by means of classical proton-proton distance constraints derived from solution-state NMR spectroscopy. NT was found to have a structure at both its N and C termini, whereas the central region of NT remains highly flexible. In TFE and HFIP solutions, the NT C-terminus presents an extended slightly incurved structure, whereas in DPC it has a beta turn. The N-terminal region of NT possesses great adaptability and accessibility to the microenvironment in the three media studied. Altogether, our work demonstrates a structure of NT fully compatible with its NTR-bound state.
-{{STRUCTURE_2oyw|  PDB=2oyw  |  SCENE=  }}
+NMR solution structure of neurotensin in membrane-mimetic environments: molecular basis for neurotensin receptor recognition.,Coutant J, Curmi PA, Toma F, Monti JP Biochemistry. 2007 May 15;46(19):5656-63. Epub 2007 Apr 19. PMID:17441729<ref>PMID:17441729</ref>
-===Neurotensin in TFE:H2O (80:20)===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_17441729}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[2oyw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYW OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:017441729</ref><references group="xtra"/>
 [[Category: Coutant, J.]]
 [[Category: Curmi, P A.]]