1iky: Difference between revisions

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[[Image:1iky.gif|left|200px]]<br /><applet load="1iky" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1iky.gif|left|200px]]
caption="1iky, resolution 3.0&Aring;" />
 
'''HIV-1 Reverse Transcriptase in Complex with the Inhibitor MSC194'''<br />
{{Structure
|PDB= 1iky |SIZE=350|CAPTION= <scene name='initialview01'>1iky</scene>, resolution 3.0&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MSD:1-[2-(3-ACETYL-2-HYDROXY-6-METHOXY-PHENYL)-CYCLOPROPYL]-3-(5-CYANO-PYRIDIN-2-YL)-THIOUREA'>MSD</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
|GENE= BH10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''HIV-1 Reverse Transcriptase in Complex with the Inhibitor MSC194'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1IKY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=MSD:'>MSD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IKY OCA].  
1IKY is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IKY OCA].  


==Reference==
==Reference==
Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant., Lindberg J, Sigurdsson S, Lowgren S, Andersson HO, Sahlberg C, Noreen R, Fridborg K, Zhang H, Unge T, Eur J Biochem. 2002 Mar;269(6):1670-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11895437 11895437]
Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant., Lindberg J, Sigurdsson S, Lowgren S, Andersson HO, Sahlberg C, Noreen R, Fridborg K, Zhang H, Unge T, Eur J Biochem. 2002 Mar;269(6):1670-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11895437 11895437]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: protein-inhibitor complex]]
[[Category: protein-inhibitor complex]]


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