1z3f: Difference between revisions

Line 1:

[[~~Image~~:1z3f.~~png|left|200px~~]]

==Structure of ellipticine in complex with a 6-bp DNA==

== Structural highlights ==

<table><tr><td colspan='2'>[[1z3f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z3F FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EL:ELLIPTICINE'>EL</scene><br>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z3f RCSB], [http://www.ebi.ac.uk/pdbsum/1z3f PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

Ellipticine is a natural plant product that has been found to be a powerful anticancer drug. Although still unclear, its mechanism of action is considered to be mainly based on DNA intercalation and/or the inhibition of topoisomerase II. Many experimental data suggest an intercalation based on stacking interactions along the major base-pair axis, but alternative binding modes have been proposed, in particular for ellipticine derivatives. The 1.5 A resolution structure of ellipticine complexed to a 6 bp oligonucleotide unveils its mode of binding and enables a detailed analysis of the distorting effects of the drug on the DNA.

~~{{STRUCTURE_1z3f| PDB=1z3f | SCENE= }}~~

The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs.,Canals A, Purciolas M, Aymami J, Coll M Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):1009-12. Epub 2005, Jun 24. PMID:15983425<ref>PMID:15983425</ref>

~~===Structure~~ of ~~ellipticine in complex with a 6-bp DNA===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_15983425}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[1z3f]] is a 2 chain structure. Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1Z3F OCA].~~

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:015983425<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Aymami, J.]]

[[Category: Canals, A.]]

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@@ Line 1: / Line 1: @@
-[[Image:1z3f.png|left|200px]]
+==Structure of ellipticine in complex with a 6-bp DNA==
+<StructureSection load='1z3f' size='340' side='right' caption='[[1z3f]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1z3f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z3F FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EL:ELLIPTICINE'>EL</scene><br>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z3f RCSB], [http://www.ebi.ac.uk/pdbsum/1z3f PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Ellipticine is a natural plant product that has been found to be a powerful anticancer drug. Although still unclear, its mechanism of action is considered to be mainly based on DNA intercalation and/or the inhibition of topoisomerase II. Many experimental data suggest an intercalation based on stacking interactions along the major base-pair axis, but alternative binding modes have been proposed, in particular for ellipticine derivatives. The 1.5 A resolution structure of ellipticine complexed to a 6 bp oligonucleotide unveils its mode of binding and enables a detailed analysis of the distorting effects of the drug on the DNA.
-{{STRUCTURE_1z3f|  PDB=1z3f  |  SCENE=  }}
+The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs.,Canals A, Purciolas M, Aymami J, Coll M Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):1009-12. Epub 2005, Jun 24. PMID:15983425<ref>PMID:15983425</ref>
-===Structure of ellipticine in complex with a 6-bp DNA===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_15983425}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1z3f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3F OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:015983425</ref><references group="xtra"/>
 [[Category: Aymami, J.]]
 [[Category: Canals, A.]]