244d: Difference between revisions

Line 1:

[[~~Image~~:244d.~~png|left|200px~~]]

==THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX==

== Structural highlights ==

<table><tr><td colspan='2'>[[244d]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=244D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=244D FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=244d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=244d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=244d RCSB], [http://www.ebi.ac.uk/pdbsum/244d PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.

~~{{STRUCTURE_244d| PDB=244d | SCENE= }}~~

The high-resolution crystal structure of a parallel-stranded guanine tetraplex.,Laughlan G, Murchie AI, Norman DG, Moore MH, Moody PC, Lilley DM, Luisi B Science. 1994 Jul 22;265(5171):520-4. PMID:8036494<ref>PMID:8036494</ref>

~~===THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_8036494}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[244d]] is~~ a ~~16 chain structure. Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=244D OCA].~~

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:008036494<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Laughlan, G.]]

[[Category: Lilley, D M.J.]]

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@@ Line 1: / Line 1: @@
-[[Image:244d.png|left|200px]]
+==THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX==
+<StructureSection load='244d' size='340' side='right' caption='[[244d]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[244d]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=244D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=244D FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=244d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=244d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=244d RCSB], [http://www.ebi.ac.uk/pdbsum/244d PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.
-{{STRUCTURE_244d|  PDB=244d  |  SCENE=  }}
+The high-resolution crystal structure of a parallel-stranded guanine tetraplex.,Laughlan G, Murchie AI, Norman DG, Moore MH, Moody PC, Lilley DM, Luisi B Science. 1994 Jul 22;265(5171):520-4. PMID:8036494<ref>PMID:8036494</ref>
-===THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_8036494}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[244d]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=244D OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:008036494</ref><references group="xtra"/>
 [[Category: Laughlan, G.]]
 [[Category: Lilley, D M.J.]]