1fmq: Difference between revisions
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[[ | ==Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG== | ||
<StructureSection load='1fmq' size='340' side='right' caption='[[1fmq]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1fmq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FMQ FirstGlance]. <br> | |||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D34:2,5-BIS{[4-(N-CYCLOBUTYLDIAMINOMETHYL)PHENYL]}FURAN'>D34</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fmq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fmq RCSB], [http://www.ebi.ac.uk/pdbsum/1fmq PDBsum]</span></td></tr> | |||
<table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds. | |||
DNA minor groove interactions and the biological activity of 2,5-bis.,Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:11128631<ref>PMID:11128631</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
< | |||
[[Category: Boykin, D W.]] | [[Category: Boykin, D W.]] | ||
[[Category: Kumar, A.]] | [[Category: Kumar, A.]] | ||
Revision as of 05:53, 8 June 2014
Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG
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