1b03: Difference between revisions

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[[~~Image~~:1b03.~~png|left|200px~~]]

==SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE==

== Structural highlights ==

<table><tr><td colspan='2'>[[1b03]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B03 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B03 FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b03 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b03 RCSB], [http://www.ebi.ac.uk/pdbsum/1b03 PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

The refined solution structure of an 18-residue HIV-1IIIB V3 peptide in complex with the Fv fragment of an anti-gp120 antibody reveals an unexpected type VI beta-turn comprising residues RGPG at the center of a beta-hairpin. The central glycine and proline of this turn are linked by a cis peptide bond. The residues of the turn interact extensively with the antibody Fv. 15N[1H] NOE measurements show that the backbone of the peptide, including the central QRGPGR loop, is well ordered in the complex. The solution structure is significantly different from the X-ray structures of HIV-1MN V3 peptides bound to anti-peptide antibodies. These differences could be due to a two-residue (QR) insertion preceding the GPGR sequence in the HIV-1IIIB strain, and the much longer peptide epitope immobilized by the anti-gp120 antibody.

~~{{STRUCTURE_1b03| PDB=1b03 | SCENE= }}~~

A cis proline turn linking two beta-hairpin strands in the solution structure of an antibody-bound HIV-1IIIB V3 peptide.,Tugarinov V, Zvi A, Levy R, Anglister J Nat Struct Biol. 1999 Apr;6(4):331-5. PMID:10201400<ref>PMID:10201400</ref>

~~===SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_10201400}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[1b03]] is~~ a ~~1 chain structure. Full experimental information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1B03 OCA].~~

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:010201400<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Anglister, J.]]

[[Category: Levy, R.]]

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@@ Line 1: / Line 1: @@
-[[Image:1b03.png|left|200px]]
+==SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE==
+<StructureSection load='1b03' size='340' side='right' caption='[[1b03]], [[NMR_Ensembles_of_Models | 35 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1b03]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B03 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B03 FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b03 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b03 RCSB], [http://www.ebi.ac.uk/pdbsum/1b03 PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The refined solution structure of an 18-residue HIV-1IIIB V3 peptide in complex with the Fv fragment of an anti-gp120 antibody reveals an unexpected type VI beta-turn comprising residues RGPG at the center of a beta-hairpin. The central glycine and proline of this turn are linked by a cis peptide bond. The residues of the turn interact extensively with the antibody Fv. 15N[1H] NOE measurements show that the backbone of the peptide, including the central QRGPGR loop, is well ordered in the complex. The solution structure is significantly different from the X-ray structures of HIV-1MN V3 peptides bound to anti-peptide antibodies. These differences could be due to a two-residue (QR) insertion preceding the GPGR sequence in the HIV-1IIIB strain, and the much longer peptide epitope immobilized by the anti-gp120 antibody.
-{{STRUCTURE_1b03|  PDB=1b03  |  SCENE=  }}
+A cis proline turn linking two beta-hairpin strands in the solution structure of an antibody-bound HIV-1IIIB V3 peptide.,Tugarinov V, Zvi A, Levy R, Anglister J Nat Struct Biol. 1999 Apr;6(4):331-5. PMID:10201400<ref>PMID:10201400</ref>
-===SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_10201400}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1b03]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B03 OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:010201400</ref><references group="xtra"/>
 [[Category: Anglister, J.]]
 [[Category: Levy, R.]]