1irx: Difference between revisions
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[[Image:1irx.gif|left|200px]] | [[Image:1irx.gif|left|200px]] | ||
'''Crystal structure of class I lysyl-tRNA synthetase''' | {{Structure | ||
|PDB= 1irx |SIZE=350|CAPTION= <scene name='initialview01'>1irx</scene>, resolution 2.6Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Lysine--tRNA_ligase Lysine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.6 6.1.1.6] | |||
|GENE= | |||
}} | |||
'''Crystal structure of class I lysyl-tRNA synthetase''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1IRX is a [ | 1IRX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IRX OCA]. | ||
==Reference== | ==Reference== | ||
Functional convergence of two lysyl-tRNA synthetases with unrelated topologies., Terada T, Nureki O, Ishitani R, Ambrogelly A, Ibba M, Soll D, Yokoyama S, Nat Struct Biol. 2002 Apr;9(4):257-62. PMID:[http:// | Functional convergence of two lysyl-tRNA synthetases with unrelated topologies., Terada T, Nureki O, Ishitani R, Ambrogelly A, Ibba M, Soll D, Yokoyama S, Nat Struct Biol. 2002 Apr;9(4):257-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11887185 11887185] | ||
[[Category: Lysine--tRNA ligase]] | [[Category: Lysine--tRNA ligase]] | ||
[[Category: Pyrococcus horikoshii]] | [[Category: Pyrococcus horikoshii]] | ||
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[[Category: rossmann fold]] | [[Category: rossmann fold]] | ||
[[Category: rsgi]] | [[Category: rsgi]] | ||
[[Category: structural | [[Category: structural genomic]] | ||
[[Category: zinc-binding structure]] | [[Category: zinc-binding structure]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:54:06 2008'' | ||
Revision as of 09:54, 20 March 2008
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| 1irx, resolution 2.6Å | |||||||||||||
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| Ligands: | ZN | ||||||||||||
| Activity: | Lysine--tRNA ligase, with EC number 6.1.1.6 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of class I lysyl-tRNA synthetase
Overview
Lysyl-tRNA can be synthesized by both a class I (LysRS-I) and a class II (LysRS-II) lysyl-tRNA synthetase. The crystal structure of LysRS-I from Pyrococcus horikoshii at 2.6 A resolution reveals extensive similarity with glutamyl-tRNA synthetase (GluRS). A comparison of the structures of LysRS-I and LysRS-II in complex with lysine shows that both enzymes use similar strategies for substrate recognition within unrelated active site topologies. A docking model based upon the GluRS-tRNA complex suggests how LysRS-I and LysRS-II can recognize the same molecular determinants in tRNALys, as shown by biochemical results, while approaching the acceptor helix of the tRNA from opposite sides.
About this Structure
1IRX is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.
Reference
Functional convergence of two lysyl-tRNA synthetases with unrelated topologies., Terada T, Nureki O, Ishitani R, Ambrogelly A, Ibba M, Soll D, Yokoyama S, Nat Struct Biol. 2002 Apr;9(4):257-62. PMID:11887185
Page seeded by OCA on Thu Mar 20 11:54:06 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Lysine--tRNA ligase
- Pyrococcus horikoshii
- Single protein
- Ambrogelly, A.
- Ibba, M.
- Ishitani, R.
- Nureki, O.
- RSGI, RIKEN Structural Genomics/Proteomics Initiative.
- Soll, D.
- Terada, T.
- Yokoyama, S.
- ZN
- Alpha-helix cage
- Beta sandwitch
- Riken structural genomics/proteomics initiative
- Rossmann fold
- Rsgi
- Structural genomic
- Zinc-binding structure
