G18secL03Tpc4: Difference between revisions
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*Primary Structure | *Primary Structure | ||
The ospC gene is located on a 27 kb circular plasmid and encodes a lipoprotein of 22–23 kDa.<ref>PMID:7679385</ref> The protein is initially synthesized with an 18-amino-acid-long signal sequence which is removed during processing and lipidation at the amino proximal Cys residue. OspC proteins are highly polymorphic and this variability extends even to strains collected from a single geographical area.<ref>D. Kumaran1, S. Eswaramoorthy1, B.J. Luft2, S. Koide3, J.J. Dunn1, C.L. Lawson1,4 and S. Swaminathan1. Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi.The EMBO Journal (2001) 20, 971 - 978 [http://dx.doi.org/DOI:10.1093/emboj/20.5.971]</ref> | The ospC gene is located on a 27 kb circular plasmid and encodes a lipoprotein of 22–23 kDa.<ref>PMID:7679385</ref> The protein is initially synthesized with an 18-amino-acid-long signal sequence which is removed during processing and lipidation at the amino proximal Cys residue. OspC proteins are highly polymorphic and this variability extends even to strains collected from a single geographical area.<ref>D. Kumaran1, S. Eswaramoorthy1, B.J. Luft2, S. Koide3, J.J. Dunn1, C.L. Lawson1,4 and S. Swaminathan1. Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi.The EMBO Journal (2001) 20, 971 - 978 [http://dx.doi.org/DOI:10.1093/emboj/20.5.971]</ref> | ||
*Secondary Structure | *Secondary Structure | ||
OspC is predominantly α-helical in its secondary structure. β-sheets are also present, but they are rather short and not promininent. | |||
*Tertiary Structure | *Tertiary Structure | ||
A single OspC subunit is composed of 5 long and 1 short α-helices. Also, 2 short segments of β-sheets are observed near the binding site of the molecule. | |||
*Quaternary Structure | |||
OspC is a dimerized molecule, with 2 identical subunits comprising a dimer. However, for a binding event to occur, 2 dimers are necessary. | |||
=== Main Function === | === Main Function === | ||
