3vuz: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of histone methyltransferase SET7/9 in comlex with AAM-1===

~~The entry 3vuz is ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/SETD7_HUMAN SETD7_HUMAN]] Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.<ref>PMID:12588998</ref><ref>PMID:15099517</ref><ref>PMID:16141209</ref><ref>PMID:17108971</ref><ref>PMID:12540855</ref><ref>PMID:15525938</ref>

~~Authors~~: ~~Niwa, H~~.~~, Handa, N~~.~~, Tomabechi, Y~~.~~, Honda, K., Toyama, M., Ohsawa, N., Shirouzu, M., Kagechika, H~~.~~, Hirano, T~~.~~, Umehara, T~~.~~, Yokoyama, S~~.

==About this Structure==

[[3vuz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VUZ OCA].

~~Description~~:

==Reference==

[[Category: Histone-lysine N-methyltransferase]]

[[Category: Homo sapiens]]

[[Category: Handa, N.]]

[[Category: Hirano, T.]]

[[Category: Honda, K.]]

[[Category: Kagechika, H.]]

[[Category: Niwa, H.]]

[[Category: Ohsawa, N.]]

[[Category: Shirouzu, M.]]

[[Category: Tomabechi, Y.]]

[[Category: Toyama, M.]]

[[Category: Umehara, T.]]

[[Category: Yokoyama, S.]]

[[Category: Adenosylmethionine binding]]

[[Category: Set domain]]

[[Category: Transferase]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_3vuz|  PDB=3vuz  |  SCENE=  }}
+===Crystal structure of histone methyltransferase SET7/9 in comlex with AAM-1===
-The entry 3vuz is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/SETD7_HUMAN SETD7_HUMAN]] Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.<ref>PMID:12588998</ref><ref>PMID:15099517</ref><ref>PMID:16141209</ref><ref>PMID:17108971</ref><ref>PMID:12540855</ref><ref>PMID:15525938</ref>
-Authors: Niwa, H., Handa, N., Tomabechi, Y., Honda, K., Toyama, M., Ohsawa, N., Shirouzu, M., Kagechika, H., Hirano, T., Umehara, T., Yokoyama, S.
+==About this Structure==
+[[3vuz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VUZ OCA].
-Description:
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Histone-lysine N-methyltransferase]]
+[[Category: Homo sapiens]]
+[[Category: Handa, N.]]
+[[Category: Hirano, T.]]
+[[Category: Honda, K.]]
+[[Category: Kagechika, H.]]
+[[Category: Niwa, H.]]
+[[Category: Ohsawa, N.]]
+[[Category: Shirouzu, M.]]
+[[Category: Tomabechi, Y.]]
+[[Category: Toyama, M.]]
+[[Category: Umehara, T.]]
+[[Category: Yokoyama, S.]]
+[[Category: Adenosylmethionine binding]]
+[[Category: Set domain]]
+[[Category: Transferase]]
+[[Category: Transferase-transferase inhibitor complex]]