4gie: Difference between revisions

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[[Image:4gie.jpg|left|200px]]
==Crystal structure of prostaglandin F synthase from Trypanosoma cruzi bound to NADP==
<StructureSection load='4gie' size='340' side='right' caption='[[4gie]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gie]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GIE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fzi|4fzi]], [[4f40|4f40]], [[4g5d|4g5d]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tc00.1047053511287.49 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 Trypanosoma cruzi])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-F_synthase Prostaglandin-F synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.188 1.1.1.188] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gie RCSB], [http://www.ebi.ac.uk/pdbsum/4gie PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/Q4DJ07_TRYCC Q4DJ07_TRYCC]] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity towards the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde (By similarity).


{{STRUCTURE_4gie|  PDB=4gie  |  SCENE=  }}
==See Also==
 
*[[Prostaglandin F synthase|Prostaglandin F synthase]]
===Crystal structure of prostaglandin F synthase from Trypanosoma cruzi bound to NADP===
__TOC__
 
</StructureSection>
 
==About this Structure==
[[4gie]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GIE OCA].
[[Category: Prostaglandin-F synthase]]
[[Category: Prostaglandin-F synthase]]
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
[[Category: Structural genomic]]
[[Category: Bimatoprost]]
[[Category: Bimatoprost]]
[[Category: Chagas disease]]
[[Category: Chagas disease]]
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[[Category: Prostaglandin d2]]
[[Category: Prostaglandin d2]]
[[Category: Rutin]]
[[Category: Rutin]]
[[Category: Seattle structural genomics center for infectious disease]]
[[Category: Ssgcid]]
[[Category: Ssgcid]]
[[Category: Structural genomic]]
[[Category: Trypanosomiasis]]
[[Category: Trypanosomiasis]]