Renin: Difference between revisions
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Familial juvenile hyperuricemic nephropathy type 2 is also caused by defects in the renin gene. Familial juvenile hyperuricemic nephropathy type 2 is characterized by slowly progressive renal failure and anemia. The autosomal dominant disorder is caused by a deletion of leucine 16 or a mutation of leucine 16 to arginine. The mutations effect the hydrophobicity of the signal sequence and disrupt the proper transport of preprorenin into the endoplasmic reticulum and thus effecting prerenin processing. The mutatnt proteins are toxic and reduce the viability of renin expressing cells, eventually causing renal failure.<ref>PMID:19664745</ref> | Familial juvenile hyperuricemic nephropathy type 2 is also caused by defects in the renin gene. Familial juvenile hyperuricemic nephropathy type 2 is characterized by slowly progressive renal failure and anemia. The autosomal dominant disorder is caused by a deletion of leucine 16 or a mutation of leucine 16 to arginine. The mutations effect the hydrophobicity of the signal sequence and disrupt the proper transport of preprorenin into the endoplasmic reticulum and thus effecting prerenin processing. The mutatnt proteins are toxic and reduce the viability of renin expressing cells, eventually causing renal failure.<ref>PMID:19664745</ref> | ||
==3D structures of renin== | |||
[[1bbs]], [[2ren]] – hRen – human<br /> | |||
[[1rne]] – hRen + transition state analog inhibitor <br /> | |||
[[1hrn]], [[1bil]], [[1bim]], [[2bks]], [[2bkt]], [[2fs4]], [[2g1n]], [[2g1o]], [[2g1r]], [[2g1s]], [[2g1y]], [[2g21]], [[2g22]], [[2g24]], [[2g26]], [[2g27]], [[2g20]], [[2i4q]], [[2iko]], [[2iku]], [[2il2]], [[2v0z]], [[2v10]], [[2v11]], [[3d91]], [[2v13]], [[2v16]], [[3gw5]], [[3g6z]], [[3g70]], [[3g72]], [[3km4]], [[3k1w]], [[3oqf]], [[3oot]], [[3oqk]], [[3oad]], [[3oag]], [[3own]], [[3o9l]], [[3q3t]], [[3sfc]], [[3q4b]], [[3q5h]], [[3vsw]], [[3vsx]] - hRen + inhibitor<br /> | |||
[[2x0b]] – hRen + angiotensinogen<br /> | |||
[[1smr]] - Ren + peptide inhibitor – mouse | |||
[[3vcm]] – h Prorenin | |||
==References== | ==References== | ||
<references /> | <references /> | ||
