G14secL04Tpc3: Difference between revisions

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Selective expression of outer surface proteins are important for the colonization and persistence within the tick vector.

It was observed that after entry into the ticks, B. burgdorferi replicates and persists within the gut, then during a subsequent blood meal, migrates through the vector and is transmitted to a new host. Other studies show that the expression of B. burgdorferi OspA and OspB is immediately turned on when the spirochetes enter and reside within the arthropod vector. However, during transmission from the arthropod vector to a vertebrate host, expression of B. burgdorferi are ~~downregulate~~. Since OspA and OspB are critical for the adherence of the spirochete to the mid-gut of the tick, if this protein is down- regulated or expressed less, then it will attach less to the mid-gut of the tick and as a result be more likely to be excreted in some way into the host on which the tick is feeding.

It was observed that after entry into the ticks, B. burgdorferi replicates and persists within the gut, then during a subsequent blood meal, migrates through the vector and is transmitted to a new host. Other studies show that the expression of B. burgdorferi OspA and OspB is immediately turned on when the spirochetes enter and reside within the arthropod vector. However, during transmission from the arthropod vector to a vertebrate host, expression of B. burgdorferi are downregulated. Since OspA and OspB are critical for the adherence of the spirochete to the mid-gut of the tick, if this protein is down- regulated or expressed less, then it will attach less to the mid-gut of the tick and as a result be more likely to be excreted in some way into the host on which the tick is feeding.

==Free OspB structure==

G14secL04Tpc3: Difference between revisions

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@@ Line 6: / Line 6: @@
 Selective expression of outer surface proteins are important for the colonization and  persistence within the tick vector.
-It was observed that after entry into the ticks, B. burgdorferi replicates and persists within the gut, then during a subsequent blood meal, migrates through the vector and is transmitted to a new host. Other studies show that the expression of B. burgdorferi OspA and OspB is immediately turned on when the spirochetes enter and reside within the arthropod vector. However, during transmission from the arthropod vector to a vertebrate host, expression  of B. burgdorferi are downregulate. Since OspA and OspB  are critical for the adherence of  the spirochete to the mid-gut of the tick, if this protein is down- regulated or expressed less, then it will attach less to the mid-gut of the tick and as a result be more likely to be excreted in some way into the host on which the tick is feeding.
+It was observed that after entry into the ticks, B. burgdorferi replicates and persists within the gut, then during a subsequent blood meal, migrates through the vector and is transmitted to a new host. Other studies show that the expression of B. burgdorferi OspA and OspB is immediately turned on when the spirochetes enter and reside within the arthropod vector. However, during transmission from the arthropod vector to a vertebrate host, expression  of B. burgdorferi are downregulated. Since OspA and OspB  are critical for the adherence of  the spirochete to the mid-gut of the tick, if this protein is down- regulated or expressed less, then it will attach less to the mid-gut of the tick and as a result be more likely to be excreted in some way into the host on which the tick is feeding.
 ==Free OspB structure==