1j1a: Difference between revisions

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[[Image:1j1a.gif|left|200px]]~~<br /><applet load~~="1j1a~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1j1a.gif|left|200px]]

~~caption="~~1j1a, resolution 2.20Å" />

'''PANCREATIC SECRETORY PHOSPHOLIPASE A2 (IIa) WITH ANTI-INFLAMMATORY ACTIVITY'''~~<br />~~

{{Structure

|PDB= 1j1a |SIZE=350|CAPTION= <scene name='initialview01'>1j1a</scene>, resolution 2.20Å

|SITE=

|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=BHP:(S)-5-(4-BENZYLOXY-PHENYL)-4-(7-PHENYL-HEPTANOYLAMINO)-PENTANOIC ACID'>BHP</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]

|GENE=

}}

'''PANCREATIC SECRETORY PHOSPHOLIPASE A2 (IIa) WITH ANTI-INFLAMMATORY ACTIVITY'''

==Overview==

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==About this Structure==

1J1A is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=BHP:'>BHP</scene> as [http://en.wikipedia.org/wiki/ligands ligands~~]. ~~Active as [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J1A OCA].

1J1A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J1A OCA].

==Reference==

D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity., Hansford KA, Reid RC, Clark CI, Tyndall JD, Whitehouse MW, Guthrie T, McGeary RP, Schafer K, Martin JL, Fairlie DP, Chembiochem. 2003 Mar 3;4(2-3):181-5. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~12616631 12616631]

D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity., Hansford KA, Reid RC, Clark CI, Tyndall JD, Whitehouse MW, Guthrie T, McGeary RP, Schafer K, Martin JL, Fairlie DP, Chembiochem. 2003 Mar 3;4(2-3):181-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12616631 12616631]

[[Category: Homo sapiens]]

[[Category: Phospholipase A(2)]]

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[[Category: inflammation]]

[[Category: medicinal chemistry]]

[[Category: structure-activity ~~relationships~~]]

[[Category: structure-activity relationship]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 13~~:17:55 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:57:37 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1j1a.gif|left|200px]]<br /><applet load="1j1a" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1j1a.gif|left|200px]]
-caption="1j1a, resolution 2.20&Aring;" />
-'''PANCREATIC SECRETORY PHOSPHOLIPASE A2 (IIa) WITH ANTI-INFLAMMATORY ACTIVITY'''<br />
+ {{Structure
+|PDB= 1j1a |SIZE=350|CAPTION= <scene name='initialview01'>1j1a</scene>, resolution 2.20&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=BHP:(S)-5-(4-BENZYLOXY-PHENYL)-4-(7-PHENYL-HEPTANOYLAMINO)-PENTANOIC ACID'>BHP</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]
+|GENE=
+}}
+'''PANCREATIC SECRETORY PHOSPHOLIPASE A2 (IIa) WITH ANTI-INFLAMMATORY ACTIVITY'''
 ==Overview==
@@ Line 10: / Line 19: @@
 ==About this Structure==
-J1A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=BHP:'>BHP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J1A OCA].
+J1A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J1A OCA].
 ==Reference==
-D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity., Hansford KA, Reid RC, Clark CI, Tyndall JD, Whitehouse MW, Guthrie T, McGeary RP, Schafer K, Martin JL, Fairlie DP, Chembiochem. 2003 Mar 3;4(2-3):181-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12616631 12616631]
+D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity., Hansford KA, Reid RC, Clark CI, Tyndall JD, Whitehouse MW, Guthrie T, McGeary RP, Schafer K, Martin JL, Fairlie DP, Chembiochem. 2003 Mar 3;4(2-3):181-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12616631 12616631]
 [[Category: Homo sapiens]]
 [[Category: Phospholipase A(2)]]
@@ Line 32: / Line 41: @@
 [[Category: inflammation]]
 [[Category: medicinal chemistry]]
-[[Category: structure-activity relationships]]
+[[Category: structure-activity relationship]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:17:55 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:57:37 2008''