G18secL03Tpc4: Difference between revisions
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*Binding and attachment to host's tissues | *Binding and attachment to host's tissues | ||
OspC may possibly be a binding protein contributing to a fundamental biological process and determining virulence of the bacteria. Several studies have shown that ''B.burgdorferi'' has a predilection for collagenous tissue and can interact with fibronectin and cellular collagens. The spirochetes can bind to a number of different cell types, including fibroblasts. ''Borrelia burgdorferi'' can bind to a novel circulating fibroblast-like cell called the peripheral blood fibrocyte, which expresses collagen types I and III as well as fibronectin, in a process that does not require OspA or OspB.<ref>PMID:10072447</ref> | OspC may possibly be a binding protein contributing to a fundamental biological process and determining virulence of the bacteria. Several studies have shown that ''B.burgdorferi'' has a predilection for collagenous tissue and can interact with fibronectin and cellular collagens. The spirochetes can bind to a number of different cell types, including fibroblasts. ''Borrelia burgdorferi'' can bind to a novel circulating fibroblast-like cell called the peripheral blood fibrocyte, which expresses collagen types I and III as well as fibronectin, in a process that does not require OspA or OspB.<ref>PMID:10072447</ref> | ||
==== Putative Binding Site ==== | ==== Putative Binding Site ==== | ||
<Structure load='1ggq' size='400' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | <Structure load='1ggq' size='400' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
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<scene name='G18secL03Tpc4/Mg_ion/1'>Mg2+</scene> between the two dimers demonstrates the location of hypothesized binding site. | <scene name='G18secL03Tpc4/Mg_ion/1'>Mg2+</scene> between the two dimers demonstrates the location of hypothesized binding site. | ||
Fibronectin in humans, according to the study of its crystal structure, is positively charged, indicating a ligand to which the bacteria can bind through the use of OspC.<ref>PMID:10075919</ref> | Fibronectin in humans, according to the study of its crystal structure, is positively charged, indicating a ligand to which the bacteria can bind through the use of OspC.<ref>PMID:10075919</ref> | ||
=== Role of OspC in Lyme Disease === | === Role of OspC in Lyme Disease === | ||
