G18secL03Tpc4: Difference between revisions
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=== Role of OspC in Lyme Disease === | === Role of OspC in Lyme Disease === | ||
Not every strain of ''B. burgoderferi'' causes Lyme disease in humans, and the type of OspC expressed indicates whether the bacteria is harmful or not. The disease causing bacteria, the invasive strains, contain OspC which has the highly negative section, like that of the B31 type, while the non-harmful strains, | Not every strain of ''B. burgoderferi'' causes Lyme disease in humans, and the type of OspC expressed indicates whether the bacteria is harmful or not. The disease causing bacteria, the invasive strains, contain OspC which has the highly negative section, like that of the B31 type, while the non-harmful strains, or non-invasive strains, lack this negative charge in that region of the protein. The negatively charged region may be involved in binding to positively charged host ligands. This suggests that the OspC protein is responsible for the pathogenicity of B. burgoderferi, and thus responsible for causing Lyme disease. | ||
=== OspC-based Vaccine Against Lyme Disease === | === OspC-based Vaccine Against Lyme Disease === | ||
