G18secL03Tpc4: Difference between revisions
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==== Main Problems with Application of OspC-based Vaccine ==== | ==== Main Problems with Application of OspC-based Vaccine ==== | ||
The major problem with creating an OspC based vaccine is a lack of knowledge regarding the three dimensional structure of the different variants of the OspC protein, especially those from invasive strains. <ref name="Green"/> The OspC [http://en.wikipedia.org/wiki/Locus_(genetics) locus]of Borrelia burgdorferi is much more variable than other genes in the species. There are 22 OspC major groups, with 15 of those found in the northeastern United States.<ref name="Brisson"/> In a | The major problem with creating an OspC based vaccine is a lack of knowledge regarding the three dimensional structure of the different variants of the OspC protein, especially those from invasive strains. <ref name="Green"/> The OspC [http://en.wikipedia.org/wiki/Locus_(genetics) locus]of Borrelia burgdorferi is much more variable than other genes in the species. There are 22 OspC major groups, with 15 of those found in the northeastern United States.<ref name="Brisson"/> In a study run by researchers at the University of California Davis, it was found that OspA genes from 3 [http://en.wikipedia.org/wiki/Genetic_isolate isolates] were greater than 99% homologous, while OspC genes shared only 81%-85% [http://en.wikipedia.org/wiki/Homology_(biology) homology]. <ref name="Cadiz">R.B. Cadiz, M. Crawford, R.B. LeFebvre, W.S Probert. Immunization with Outer Surface Protein (Osp) A, but Not OspC, Provides Cross-Protection of Mice Challenged with North American Isolates of ''Borrelia'' ''Burgdorferi''. The Journal of Infectious Diseases 1997; Volume 175: 400-405. [http://www.jstor.org/discover/10.2307/30131660?uid=3739832&uid=2&uid=4&uid=3739256&sid=21101134072011]</ref> The genetic and antigenic [http://en.wikipedia.org/wiki/Genetic_heterogeneity heterogeneity] associated with OspC, but not OspA, may limit the effectiveness of an OspC based vaccine, since the vaccine would not protect against all of the strains. <ref name="Cadiz"/> | ||
=== Necessity of Further Research on OspC === | === Necessity of Further Research on OspC === | ||
