G13secL03Tpc3: Difference between revisions
From Proteopedia
Jump to navigationJump to search
| Line 23: | Line 23: | ||
==Application== | ==Application== | ||
Under pressure in the presence of antibodies, OspB is capable of existing in various forms. Mutations occur in the residue of Lysine 253, the epitope of H6831, and may prevent Borrelia from being recognized and lysed by bactericidal Fabs such as H6381. <ref name=Article4> PMID: 15128807 </ref> The study of this structure of Osp B is important to combat future mechanisms of curing Lyme disease. Vaccines created to specifically fight OspB have not yet been successful, due to the increased variability of the | Under pressure in the presence of antibodies, OspB is capable of existing in various forms. Mutations occur in the residue of Lysine 253, the epitope of H6831, and may prevent ''Borrelia'' from being recognized and lysed by bactericidal Fabs such as H6381. <ref name=Article4> PMID: 15128807 </ref> The study of this structure of Osp B is important to combat future mechanisms of curing Lyme disease. Vaccines created to specifically fight OspB have not yet been successful, due to the increased variability of the epitope. Vaccine are not yet able to counteract the varied strains of ''Borrelia burgdorferi.'' However, the ability of H6381 and CB2 to make the bacteria subject to increased proteolytic activity is a possibility for future research, as it is still currently misunderstood. | ||
References: {{reflist}} | References: {{reflist}} | ||
