G09SecL04Tpc2: Difference between revisions

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Besides OspA, there are other outer surface proteins, including OspB, OspC, and Vls, which are very important for the transmission of Lyme Disease from the tick to the host, as well as establishing the infection via bloodstream disseminating throughout the host body. Early symptoms of Lyme Disease include skin lesions and rashes that have a characteristic bulls-eye appearance known as [http://en.wikipedia.org/wiki/Erythema_chronicum_migrans erythema chronicum migrans (ECM)]. It is important to note that ECM can be used for early diagnosis of Lyme Disease prior to awaiting more accurate laboratory tests. <ref name=art2>PMID:17029130</ref>

Upon infection, OspA is immediately downregulated or can even be turned off. Because of this, vaccinations for OspA are virtually ineffective once spirochetes have entered the host. Downregulation also makes OspA harder to detect; OspA is usually upregulated in the late stages of the disease and leads to more serious inflammatory disorders in the central nervous system.

Upon infection, OspA is immediately downregulated or can even be turned off. Because of this, vaccinations for OspA are virtually ineffective once spirochetes have entered the host. Downregulation also makes OspA harder to detect; OspA is usually upregulated in the late stages of the disease and leads to more serious inflammatory disorders in the central nervous system such as acute Lyme [http://en.wikipedia.org/wiki/Neuroborreliosis neuroborreliosis] (LNB).

G09SecL04Tpc2: Difference between revisions

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Revision as of 15:36, 16 August 2012 view source Nabil Faridi (talk \| contribs) 69 edits No edit summary ← Older edit		Revision as of 15:41, 16 August 2012 view source Nabil Faridi (talk \| contribs) 69 edits No edit summary Newer edit →
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	Besides OspA, there are other outer surface proteins, including OspB, OspC, and Vls, which are very important for the transmission of Lyme Disease from the tick to the host, as well as establishing the infection via bloodstream disseminating throughout the host body. Early symptoms of Lyme Disease include skin lesions and rashes that have a characteristic bulls-eye appearance known as [http://en.wikipedia.org/wiki/Erythema_chronicum_migrans erythema chronicum migrans (ECM)]. It is important to note that ECM can be used for early diagnosis of Lyme Disease prior to awaiting more accurate laboratory tests. <ref name=art2>PMID:17029130</ref>		Besides OspA, there are other outer surface proteins, including OspB, OspC, and Vls, which are very important for the transmission of Lyme Disease from the tick to the host, as well as establishing the infection via bloodstream disseminating throughout the host body. Early symptoms of Lyme Disease include skin lesions and rashes that have a characteristic bulls-eye appearance known as [http://en.wikipedia.org/wiki/Erythema_chronicum_migrans erythema chronicum migrans (ECM)]. It is important to note that ECM can be used for early diagnosis of Lyme Disease prior to awaiting more accurate laboratory tests. <ref name=art2>PMID:17029130</ref>

	Upon infection, OspA is immediately downregulated or can even be turned off. Because of this, vaccinations for OspA are virtually ineffective once spirochetes have entered the host. Downregulation also makes OspA harder to detect; OspA is usually upregulated in the late stages of the disease and leads to more serious inflammatory disorders in the central nervous system.		Upon infection, OspA is immediately downregulated or can even be turned off. Because of this, vaccinations for OspA are virtually ineffective once spirochetes have entered the host. Downregulation also makes OspA harder to detect; OspA is usually upregulated in the late stages of the disease and leads to more serious inflammatory disorders in the central nervous system such as acute Lyme [http://en.wikipedia.org/wiki/Neuroborreliosis neuroborreliosis] (LNB).