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===Symptoms and Origin of Lyme disease===

[http://en.wikipedia.org/wiki/Lyme_disease Lyme disease] is caused by the bacterial spirochete[http://en.wikipedia.org/wiki/Borrelia_burgdorferi ''Borrelia burgdorferi'']. It is an inflammatory disorder that usually begins with skin lesions known as [http://en.wikipedia.org/wiki/Erythema_chronicum_migrans erythema chronicum migrands (ECM)]<ref name ="sbu">Willy Burgdorfer, Alan G. Barbour, Stanley F. Hayes, Jorge L. Benach, Edgar Grunwaldt and Jeffrey P. Davis Science , New Series, Vol. 216, No. 4552 (Jun. 18, 1982), pp. 1317-1319 http://www.jstor.org/stable/1689391</ref>. Months later the skin lesion can be followed by cardiac or neurological symptoms, migratory polyarthritis, oligoarticular arthritis, and chronic arthritis in the knees<ref name="sbu" />. The disease was first recognized as a new form of inflammatory arthritis in Lyme, ~~Conneticuit~~ in 1975. Since then, the disease has been reported from many other parts of the United States<ref name="sbu" />.

[http://en.wikipedia.org/wiki/Lyme_disease Lyme disease] is caused by the bacterial spirochete[http://en.wikipedia.org/wiki/Borrelia_burgdorferi ''Borrelia burgdorferi'']. It is an inflammatory disorder that usually begins with skin lesions known as [http://en.wikipedia.org/wiki/Erythema_chronicum_migrans erythema chronicum migrands (ECM)]<ref name ="sbu">Willy Burgdorfer, Alan G. Barbour, Stanley F. Hayes, Jorge L. Benach, Edgar Grunwaldt and Jeffrey P. Davis Science , New Series, Vol. 216, No. 4552 (Jun. 18, 1982), pp. 1317-1319 http://www.jstor.org/stable/1689391</ref>. Months later the skin lesion can be followed by cardiac or neurological symptoms, migratory polyarthritis, oligoarticular arthritis, and chronic arthritis in the knees<ref name="sbu" />. The disease was first recognized as a new form of inflammatory arthritis in Lyme, Connecticut in 1975. Since then, the disease has been reported from many other parts of the United States<ref name="sbu" />.

===Outer Surface Proteins===

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 ===Symptoms and Origin of Lyme disease===
-[http://en.wikipedia.org/wiki/Lyme_disease Lyme disease] is caused by the bacterial spirochete[http://en.wikipedia.org/wiki/Borrelia_burgdorferi ''Borrelia burgdorferi'']. It is an inflammatory disorder that usually begins with skin lesions known as [http://en.wikipedia.org/wiki/Erythema_chronicum_migrans erythema chronicum migrands (ECM)]<ref name ="sbu">Willy Burgdorfer, Alan G. Barbour, Stanley F. Hayes, Jorge L. Benach, Edgar Grunwaldt and Jeffrey P. Davis Science , New Series, Vol. 216, No. 4552 (Jun. 18, 1982), pp. 1317-1319 http://www.jstor.org/stable/1689391</ref>. Months later the skin lesion can be followed by cardiac or neurological symptoms, migratory polyarthritis, oligoarticular arthritis, and chronic arthritis in the knees<ref name="sbu" />. The disease was first recognized as a new form of inflammatory arthritis in Lyme, Conneticuit in 1975. Since then, the disease has been reported from many other parts of the United States<ref name="sbu" />.
+[http://en.wikipedia.org/wiki/Lyme_disease Lyme disease] is caused by the bacterial spirochete[http://en.wikipedia.org/wiki/Borrelia_burgdorferi ''Borrelia burgdorferi'']. It is an inflammatory disorder that usually begins with skin lesions known as [http://en.wikipedia.org/wiki/Erythema_chronicum_migrans erythema chronicum migrands (ECM)]<ref name ="sbu">Willy Burgdorfer, Alan G. Barbour, Stanley F. Hayes, Jorge L. Benach, Edgar Grunwaldt and Jeffrey P. Davis Science , New Series, Vol. 216, No. 4552 (Jun. 18, 1982), pp. 1317-1319 http://www.jstor.org/stable/1689391</ref>. Months later the skin lesion can be followed by cardiac or neurological symptoms, migratory polyarthritis, oligoarticular arthritis, and chronic arthritis in the knees<ref name="sbu" />. The disease was first recognized as a new form of inflammatory arthritis in Lyme, Connecticut in 1975. Since then, the disease has been reported from many other parts of the United States<ref name="sbu" />.
 ===Outer Surface Proteins===