G14secL04Tpc3: Difference between revisions

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Selective expression of outer surface proteins are important for the colonization and persistence within the tick vector.

It was observed that after entry into the ticks, B. burgdorferi replicates and persists within the gut, then during a subsequent blood meal, migrates through the vector and is transmitted to a new host.<ref name="transmit">De Silva AM, Fikrig E (1995) Growth and migration of ''Borrelia burgdorferi'' in Ixodes ticks during blood feeding. Am J Trop Med Hyg 53: 397–404. http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&doptcmdl=Citation&defaultField=Title%20Word&term=De%20Silva%5Bauthor%5D%20AND%20Growth%20and%20migration%20of%20Borrelia%20burgdorferi%20in%20Ixodes%20ticks%20during%20blood%20feeding</ref>. Other studies show that the expression of ~~B. burgdorferi~~ OspA and OspB is immediately turned on when the spirochetes enter and reside within the arthropod vector<ref name="transmit" />. However, during transmission from the arthropod vector to a vertebrate host, expression of OspA and OspB are downregulated while OspC is upregulated <ref name="transmit" />. Since OspA and OspB are critical for the adherence of the spirochete to the mid-gut of the tick, if ~~this protein is~~ down- regulated or expressed less, then it will attach less to the mid-gut of the tick and as a result be more likely to be excreted in some way into the host on which the tick is feeding.

It was observed that after entry into the ticks, ''B. burgdorferi'' replicates and persists within the gut, then during a subsequent blood meal, migrates through the vector and is transmitted to a new host.<ref name="transmit">De Silva AM, Fikrig E (1995) Growth and migration of ''Borrelia burgdorferi'' in Ixodes ticks during blood feeding. Am J Trop Med Hyg 53: 397–404. http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&doptcmdl=Citation&defaultField=Title%20Word&term=De%20Silva%5Bauthor%5D%20AND%20Growth%20and%20migration%20of%20Borrelia%20burgdorferi%20in%20Ixodes%20ticks%20during%20blood%20feeding</ref>. Other studies show that the expression of OspA and OspB is immediately turned on when the spirochetes enter and reside within the arthropod vector<ref name="transmit" />. However, during transmission from the arthropod vector to a vertebrate host, expression of OspA and OspB are downregulated while OspC is upregulated <ref name="transmit" />. Since OspA and OspB are critical for the adherence of the spirochete to the mid-gut of the tick, if these proteins are down-regulated or expressed less, then the spirochete will attach less to the mid-gut of the tick and as a result be more likely to be excreted in some way into the host on which the tick is feeding.

==Free OspB structure==

G14secL04Tpc3: Difference between revisions

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@@ Line 14: / Line 14: @@
 Selective expression of outer surface proteins are important for the colonization and  persistence within the tick vector.
-It was observed that after entry into the ticks, B. burgdorferi replicates and persists within the gut, then during a subsequent blood meal, migrates through the vector and is transmitted to a new host.<ref name="transmit">De Silva AM, Fikrig E (1995) Growth and migration of ''Borrelia burgdorferi'' in Ixodes ticks during blood feeding. Am J Trop Med Hyg 53: 397–404. http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&doptcmdl=Citation&defaultField=Title%20Word&term=De%20Silva%5Bauthor%5D%20AND%20Growth%20and%20migration%20of%20Borrelia%20burgdorferi%20in%20Ixodes%20ticks%20during%20blood%20feeding</ref>. Other studies show that the expression of B. burgdorferi OspA and OspB is immediately turned on when the spirochetes enter and reside within the arthropod vector<ref name="transmit" />. However, during transmission from the arthropod vector to a vertebrate host, expression of OspA and OspB are downregulated while OspC is upregulated <ref name="transmit" />. Since OspA and OspB  are critical for the adherence of  the spirochete to the mid-gut of the tick, if this protein is down- regulated or expressed less, then it will attach less to the mid-gut of the tick and as a result be more likely to be excreted in some way into the host on which the tick is feeding.
+It was observed that after entry into the ticks, ''B. burgdorferi'' replicates and persists within the gut, then during a subsequent blood meal, migrates through the vector and is transmitted to a new host.<ref name="transmit">De Silva AM, Fikrig E (1995) Growth and migration of ''Borrelia burgdorferi'' in Ixodes ticks during blood feeding. Am J Trop Med Hyg 53: 397–404. http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&doptcmdl=Citation&defaultField=Title%20Word&term=De%20Silva%5Bauthor%5D%20AND%20Growth%20and%20migration%20of%20Borrelia%20burgdorferi%20in%20Ixodes%20ticks%20during%20blood%20feeding</ref>. Other studies show that the expression of OspA and OspB is immediately turned on when the spirochetes enter and reside within the arthropod vector<ref name="transmit" />. However, during transmission from the arthropod vector to a vertebrate host, expression of OspA and OspB are downregulated while OspC is upregulated <ref name="transmit" />. Since OspA and OspB  are critical for the adherence of  the spirochete to the mid-gut of the tick, if these proteins are down-regulated or expressed less, then the spirochete will attach less to the mid-gut of the tick and as a result be more likely to be excreted in some way into the host on which the tick is feeding.
 ==Free OspB structure==