2rsv: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Solution structure of human full-length vaccinia related kinase 1 (VRK1)===

The entry ~~2rsv is ON HOLD until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.

~~Authors~~: ~~Koshiba~~, S.~~, Tochio, N~~., ~~Yokoyama, J~~.~~, Kigawa, T~~.

==Function==

[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>

~~Description~~: ~~Solution structure of human full~~-~~length vaccinia related~~ kinase ~~1 (VRK1)~~

==About this Structure==

[[2rsv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RSV OCA].

==Reference==

[[Category: Non-specific serine/threonine protein kinase]]

[[Category: Kigawa, T.]]

[[Category: Koshiba, S.]]

[[Category: Tochio, N.]]

[[Category: Yokoyama, J.]]

[[Category: Kinase]]

[[Category: Transferase]]

[[Category: Vrk]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Large structure}}
+{{STRUCTURE_2rsv|  PDB=2rsv  |  SCENE=  }}
+===Solution structure of human full-length vaccinia related kinase 1 (VRK1)===
-The entry 2rsv is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.
-Authors: Koshiba, S., Tochio, N., Yokoyama, J., Kigawa, T.
+==Function==
+[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>
-Description: Solution structure of human full-length vaccinia related kinase 1 (VRK1)
+==About this Structure==
+[[2rsv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RSV OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Kigawa, T.]]
+[[Category: Koshiba, S.]]
+[[Category: Tochio, N.]]
+[[Category: Yokoyama, J.]]
+[[Category: Kinase]]
+[[Category: Transferase]]
+[[Category: Vrk]]