4geb: Difference between revisions
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{{STRUCTURE_4geb| PDB=4geb | SCENE= }} | |||
===Kynurenine Aminotransferase II Inhibitors=== | |||
{{ABSTRACT_PUBMED_23466229}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN]] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref> | |||
==About this Structure== | |||
[[4geb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEB OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023466229</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Pandit, J.]] | |||
[[Category: Aminotransferase]] | |||
[[Category: Irreversible inhibitor]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||