4b72: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Aminoimidazoles as BACE-1 Inhibitors: From De Novo Design to Ab- lowering in Brain===

~~The entry 4b72~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>

~~Authors~~: ~~Gravenfors, Y~~.~~, Blid, J~~.~~, Ginman, T~~.~~, Karlstrom, S., Kihlstrom, J., Kolmodin, K., Lindstrom, J., Berg, S., Kieseritzky, F., Slivo, C., Swahn, B., Viklund, J., Olsson, L., Johansson, P., Eketjall, S., Falting, J., Jeppsson, F~~.~~, Stromberg, K~~.~~, Janson, J~~.~~, Rahm, F~~.

==About this Structure==

[[4b72]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B72 OCA].

~~Description~~: ~~Aminoimidazoles as BACE-1 Inhibitors~~: ~~From De Novo Design to Ab~~-~~lowering in Brain~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Memapsin 2]]

[[Category: Berg, S.]]

[[Category: Blid, J.]]

[[Category: Eketjall, S.]]

[[Category: Falting, J.]]

[[Category: Ginman, T.]]

[[Category: Gravenfors, Y.]]

[[Category: Janson, J.]]

[[Category: Jeppsson, F.]]

[[Category: Johansson, P.]]

[[Category: Karlstrom, S.]]

[[Category: Kieseritzky, F.]]

[[Category: Kihlstrom, J.]]

[[Category: Kolmodin, K.]]

[[Category: Lindstrom, J.]]

[[Category: Olsson, L.]]

[[Category: Rahm, F.]]

[[Category: Slivo, C.]]

[[Category: Stromberg, K.]]

[[Category: Swahn, B.]]

[[Category: Viklund, J.]]

[[Category: Hydrolase]]

[[Category: Hydrolase inhibitor]]

[[Category: Lead generation]]

[[Category: Structure-based drug design]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4b72|  PDB=4b72  |  SCENE=  }}
+===Aminoimidazoles as BACE-1 Inhibitors: From De Novo Design to Ab- lowering in Brain===
+{{ABSTRACT_PUBMED_23126626}}
-The entry 4b72 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
-Authors: Gravenfors, Y., Blid, J., Ginman, T., Karlstrom, S., Kihlstrom, J., Kolmodin, K., Lindstrom, J., Berg, S., Kieseritzky, F., Slivo, C., Swahn, B., Viklund, J., Olsson, L., Johansson, P., Eketjall, S., Falting, J., Jeppsson, F., Stromberg, K., Janson, J., Rahm, F.
+==About this Structure==
+[[4b72]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B72 OCA].
-Description: Aminoimidazoles as BACE-1 Inhibitors: From De Novo Design to Ab-lowering in Brain
+==Reference==
+<ref group="xtra">PMID:023126626</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Memapsin 2]]
+[[Category: Berg, S.]]
+[[Category: Blid, J.]]
+[[Category: Eketjall, S.]]
+[[Category: Falting, J.]]
+[[Category: Ginman, T.]]
+[[Category: Gravenfors, Y.]]
+[[Category: Janson, J.]]
+[[Category: Jeppsson, F.]]
+[[Category: Johansson, P.]]
+[[Category: Karlstrom, S.]]
+[[Category: Kieseritzky, F.]]
+[[Category: Kihlstrom, J.]]
+[[Category: Kolmodin, K.]]
+[[Category: Lindstrom, J.]]
+[[Category: Olsson, L.]]
+[[Category: Rahm, F.]]
+[[Category: Slivo, C.]]
+[[Category: Stromberg, K.]]
+[[Category: Swahn, B.]]
+[[Category: Viklund, J.]]
+[[Category: Hydrolase]]
+[[Category: Hydrolase inhibitor]]
+[[Category: Lead generation]]
+[[Category: Structure-based drug design]]