1jg0: Difference between revisions

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[[Image:1jg0.jpg|left|200px]]<br /><applet load="1jg0" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1jg0.jpg|left|200px]]
caption="1jg0, resolution 2.00&Aring;" />
 
'''Crystal structure of Escherichia coli thymidylate synthase complexed with 2'-deoxyuridine-5'-monophosphate and N,O-didansyl-L-tyrosine'''<br />
{{Structure
|PDB= 1jg0 |SIZE=350|CAPTION= <scene name='initialview01'>1jg0</scene>, resolution 2.00&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=UMP:2'-DEOXYURIDINE+5'-MONOPHOSPHATE'>UMP</scene> and <scene name='pdbligand=DDT:N,O-DIDANSYL-L-TYROSINE'>DDT</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
|GENE= Esherichia coli ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''Crystal structure of Escherichia coli thymidylate synthase complexed with 2'-deoxyuridine-5'-monophosphate and N,O-didansyl-L-tyrosine'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1JG0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=UMP:'>UMP</scene> and <scene name='pdbligand=DDT:'>DDT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JG0 OCA].  
1JG0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JG0 OCA].  


==Reference==
==Reference==
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase., Fritz TA, Tondi D, Finer-Moore JS, Costi MP, Stroud RM, Chem Biol. 2001 Oct;8(10):981-95. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11590022 11590022]
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase., Fritz TA, Tondi D, Finer-Moore JS, Costi MP, Stroud RM, Chem Biol. 2001 Oct;8(10):981-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11590022 11590022]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: thymidylate synthase]]
[[Category: thymidylate synthase]]


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