1jk8: Difference between revisions
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[[Image:1jk8.jpg|left|200px]] | [[Image:1jk8.jpg|left|200px]] | ||
'''Crystal structure of a human insulin peptide-HLA-DQ8 complex''' | {{Structure | ||
|PDB= 1jk8 |SIZE=350|CAPTION= <scene name='initialview01'>1jk8</scene>, resolution 2.40Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Crystal structure of a human insulin peptide-HLA-DQ8 complex''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1JK8 is a [ | 1JK8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JK8 OCA]. | ||
==Reference== | ==Reference== | ||
Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes., Lee KH, Wucherpfennig KW, Wiley DC, Nat Immunol. 2001 Jun;2(6):501-7. PMID:[http:// | Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes., Lee KH, Wucherpfennig KW, Wiley DC, Nat Immunol. 2001 Jun;2(6):501-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11376336 11376336] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: type 1 diabetes]] | [[Category: type 1 diabetes]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:04:31 2008'' | ||
Revision as of 10:04, 20 March 2008
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| 1jk8, resolution 2.40Å | |||||||||||||
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| Ligands: | NAG | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of a human insulin peptide-HLA-DQ8 complex
Overview
The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2 in humans and I-A(g7) in nonobese diabetic (NOD) mice are the major risk factors for increased susceptibility to type 1 diabetes. Using X-ray crystallography, we have determined the three-dimensional structure of DQ8 complexed with an immunodominant peptide from insulin. The similarity of the DQ8, DQ2 and I-A(g7) peptide-binding pockets suggests that diabetes is caused by the same antigen-presentation event(s) in humans and NOD mice. Correlating type 1 diabetes epidemiology and MHC sequences with the DQ8 structure suggests that other structural features of the P9 pocket in addition to position 57 contribute to susceptibility to type 1 diabetes.
Disease
Known diseases associated with this structure: Celiac disease, susceptibility to OMIM:[146880], Diabetes mellitus, rare form OMIM:[176730], Hyperproinsulinemia, familial OMIM:[176730], MODY, one form OMIM:[176730]
About this Structure
1JK8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes., Lee KH, Wucherpfennig KW, Wiley DC, Nat Immunol. 2001 Jun;2(6):501-7. PMID:11376336
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