1jkx: Difference between revisions

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[[Image:1jkx.gif|left|200px]]<br /><applet load="1jkx" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1jkx.gif|left|200px]]
caption="1jkx, resolution 1.60&Aring;" />
 
'''Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase'''<br />
{{Structure
|PDB= 1jkx |SIZE=350|CAPTION= <scene name='initialview01'>1jkx</scene>, resolution 1.60&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=138:N-[5'-O-PHOSPHONO-RIBOFURANOSYL]-2-[2-HYDROXY-2-[4-[GLUTAMIC ACID]-N-CARBONYLPHENYL]-3-[2-AMINO-4-HYDROXY-QUINAZOLIN-6-YL]-PROPANYLAMINO]-ACETAMIDE'>138</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2]
|GENE= PURN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1JKX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=138:'>138</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKX OCA].  
1JKX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKX OCA].  


==Reference==
==Reference==
Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase., Greasley SE, Marsilje TH, Cai H, Baker S, Benkovic SJ, Boger DL, Wilson IA, Biochemistry. 2001 Nov 13;40(45):13538-47. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11695901 11695901]
Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase., Greasley SE, Marsilje TH, Cai H, Baker S, Benkovic SJ, Boger DL, Wilson IA, Biochemistry. 2001 Nov 13;40(45):13538-47. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11695901 11695901]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Phosphoribosylglycinamide formyltransferase]]
[[Category: Phosphoribosylglycinamide formyltransferase]]
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[[Category: purine biosynthesis]]
[[Category: purine biosynthesis]]


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Retrieved from "https://proteopedia.org/1jkx"