1jla: Difference between revisions

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[[Image:1jla.gif|left|200px]]<br /><applet load="1jla" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1jla.gif|left|200px]]
caption="1jla, resolution 2.50&Aring;" />
 
'''CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-651'''<br />
{{Structure
|PDB= 1jla |SIZE=350|CAPTION= <scene name='initialview01'>1jla</scene>, resolution 2.50&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=TNK:6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL'>TNK</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
|GENE= POl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Human immunodeficiency virus type 1 (isolate HXB2)]), POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Human immunodeficiency virus type 1 (isolate HXB2)])
}}
 
'''CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-651'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1JLA is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_hxb2) Human immunodeficiency virus type 1 (isolate hxb2)] with <scene name='pdbligand=TNK:'>TNK</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLA OCA].  
1JLA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_hxb2) Human immunodeficiency virus type 1 (isolate hxb2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLA OCA].  


==Reference==
==Reference==
Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors., Ren J, Nichols C, Bird L, Chamberlain P, Weaver K, Short S, Stuart DI, Stammers DK, J Mol Biol. 2001 Sep 28;312(4):795-805. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11575933 11575933]
Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors., Ren J, Nichols C, Bird L, Chamberlain P, Weaver K, Short S, Stuart DI, Stammers DK, J Mol Biol. 2001 Sep 28;312(4):795-805. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11575933 11575933]
[[Category: Human immunodeficiency virus type 1 (isolate hxb2)]]
[[Category: Human immunodeficiency virus type 1 (isolate hxb2)]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Weaver, K.]]
[[Category: Weaver, K.]]
[[Category: TNK]]
[[Category: TNK]]
[[Category: aids]]
[[Category: aid]]
[[Category: drug design]]
[[Category: drug design]]
[[Category: drug resistance mutations]]
[[Category: drug resistance mutation]]
[[Category: hiv-1 reverse transcriptase]]
[[Category: hiv-1 reverse transcriptase]]
[[Category: non-nucleoside inhibitor]]
[[Category: non-nucleoside inhibitor]]
[[Category: tnk-651]]
[[Category: tnk-651]]


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