4gky: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of a carbohydrate-binding domain===

~~The~~ entry ~~4gky~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/LMAN1_HUMAN LMAN1_HUMAN]] Defects in LMAN1 are THE cause of factor V and factor VIII combined deficiency type 1 (F5F8D1) [MIM:[http://omim.org/entry/227300 227300]]; also known as multiple coagulation factor deficiency I (MCFD1). F5F8D1 is an autosomal recessive blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal.<ref>PMID:10090935</ref>

~~Authors~~: ~~Page~~, R.C.

==Function==

[[http://www.uniprot.org/uniprot/LMAN1_HUMAN LMAN1_HUMAN]] Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.<ref>PMID:13130098</ref> <ref>PMID:12717434</ref>

~~Description~~: ~~Crystal structure of a carbohydrate~~-~~binding domain~~

==About this Structure==

[[4gky]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GKY OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Misra, S.]]

[[Category: Nix, J C.]]

[[Category: Page, R C.]]

[[Category: Zhang, B.]]

[[Category: Zheng, C.]]

[[Category: Endoplasmic reticulum]]

[[Category: Protein transport]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4gky|  PDB=4gky  |  SCENE=  }}
+===Crystal structure of a carbohydrate-binding domain===
+{{ABSTRACT_PUBMED_23709226}}
-The entry 4gky is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/LMAN1_HUMAN LMAN1_HUMAN]] Defects in LMAN1 are THE cause of factor V and factor VIII combined deficiency type 1 (F5F8D1) [MIM:[http://omim.org/entry/227300 227300]]; also known as multiple coagulation factor deficiency I (MCFD1). F5F8D1 is an autosomal recessive blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal.<ref>PMID:10090935</ref>
-Authors: Page, R.C.
+==Function==
+[[http://www.uniprot.org/uniprot/LMAN1_HUMAN LMAN1_HUMAN]] Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.<ref>PMID:13130098</ref> <ref>PMID:12717434</ref>
-Description: Crystal structure of a carbohydrate-binding domain
+==About this Structure==
+[[4gky]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GKY OCA].
+==Reference==
+<ref group="xtra">PMID:023709226</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Misra, S.]]
+[[Category: Nix, J C.]]
+[[Category: Page, R C.]]
+[[Category: Zhang, B.]]
+[[Category: Zheng, C.]]
+[[Category: Endoplasmic reticulum]]
+[[Category: Protein transport]]