Group:MUZIC:MLP: Difference between revisions
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All three CSRPs are associated with the actin cytoskeleton and have similar functions in different muscle varieties. CSRP3 is localized in Z and M-lines in striated muscles. | All three CSRPs are associated with the actin cytoskeleton and have similar functions in different muscle varieties. CSRP3 is localized in Z and M-lines in striated muscles. | ||
The interactions of CSRP3 with [[telethonin]] has been reported previously<ref>PMID: 12507422</ref>, <ref>PMID: 16407954</ref>, however recent reports demonstrate that this interaction is not existing <ref>PMID:18505755</ref>. | The interactions of CSRP3 with [[telethonin]] has been reported previously<ref>PMID: 12507422</ref>, <ref>PMID: 16407954</ref>, however recent reports demonstrate that this interaction is not existing <ref>PMID:18505755</ref>. | ||
CSRP3 is mainly | CSRP3 is mainly interacting with [[α-actinin 2]] as well as has been suggested to interact with βI-spectrin, N-RAP (Nebulin-related-anchoring protein) and cofilin2 (CFL2), underlying the essential role of CSRP3 as a scaffold protein in the sarcomere. During myofibrilogenesis CSRP3 has been suggested to form complexes with the muscle helix-loop-helix transcription factors MyoD, MRF4 and myogenin <ref>PMID:18505755</ref>. | ||
== Pathology == | == Pathology == | ||
