4b7p: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of HSP90 with NMS-E973 inhibitor bound===

~~The entry 4b7p~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>

~~Authors~~: ~~Fogliatto, G~~.~~, Gianellini, L~~.~~, Brasca, M~~.G., Casale, E., Ballinari, D., Ciomei, M., Degrassi, A., De Ponti, A., Germani, M., Guanci, M., Paolucci, M., Polucci, P., Russo, M., Sola, F., Valsasina, B., Visco, C., Zuccotto, F., Donati, D., Felder, E., Galvani, A.~~, Pesenti, E~~.~~, Mantegani, S~~.~~, Isacchi, A~~.

==About this Structure==

[[4b7p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7P OCA].

~~Description~~: ~~Structure of HSP90 with NMS~~-~~E973 inhibitor bound~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Ballinari, D.]]

[[Category: Brasca, M G.]]

[[Category: Casale, E.]]

[[Category: Ciomei, M.]]

[[Category: Degrassi, A.]]

[[Category: Donati, D.]]

[[Category: Felder, E.]]

[[Category: Fogliatto, G.]]

[[Category: Galvani, A.]]

[[Category: Germani, M.]]

[[Category: Gianellini, L.]]

[[Category: Guanci, M.]]

[[Category: Isacchi, A.]]

[[Category: Mantegani, S.]]

[[Category: Paolucci, M.]]

[[Category: Pesenti, E.]]

[[Category: Polucci, P.]]

[[Category: Ponti, A De.]]

[[Category: Russo, M.]]

[[Category: Sola, F.]]

[[Category: Valsasina, B.]]

[[Category: Visco, C.]]

[[Category: Zuccotto, F.]]

[[Category: Atp-binding]]

[[Category: Atpase]]

[[Category: Chaperone]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4b7p|  PDB=4b7p  |  SCENE=  }}
+===Structure of HSP90 with NMS-E973 inhibitor bound===
+{{ABSTRACT_PUBMED_23674492}}
-The entry 4b7p is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
-Authors: Fogliatto, G., Gianellini, L., Brasca, M.G., Casale, E., Ballinari, D., Ciomei, M., Degrassi, A., De Ponti, A., Germani, M., Guanci, M., Paolucci, M., Polucci, P., Russo, M., Sola, F., Valsasina, B., Visco, C., Zuccotto, F., Donati, D., Felder, E., Galvani, A., Pesenti, E., Mantegani, S., Isacchi, A.
+==About this Structure==
+[[4b7p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7P OCA].
-Description: Structure of HSP90 with NMS-E973 inhibitor bound
+==Reference==
+<ref group="xtra">PMID:023674492</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Ballinari, D.]]
+[[Category: Brasca, M G.]]
+[[Category: Casale, E.]]
+[[Category: Ciomei, M.]]
+[[Category: Degrassi, A.]]
+[[Category: Donati, D.]]
+[[Category: Felder, E.]]
+[[Category: Fogliatto, G.]]
+[[Category: Galvani, A.]]
+[[Category: Germani, M.]]
+[[Category: Gianellini, L.]]
+[[Category: Guanci, M.]]
+[[Category: Isacchi, A.]]
+[[Category: Mantegani, S.]]
+[[Category: Paolucci, M.]]
+[[Category: Pesenti, E.]]
+[[Category: Polucci, P.]]
+[[Category: Ponti, A De.]]
+[[Category: Russo, M.]]
+[[Category: Sola, F.]]
+[[Category: Valsasina, B.]]
+[[Category: Visco, C.]]
+[[Category: Zuccotto, F.]]
+[[Category: Atp-binding]]
+[[Category: Atpase]]
+[[Category: Chaperone]]