Sandbox Reserved 390: Difference between revisions

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=== '''Human topoisomerase IIbeta in complex with DNA and etoposide''' ===

Crystal structure of a large fragment of human type II topoisomerases (TOP2) complexed to DNA and to the anticancer drug etoposide to reveal structural details of drug-induced stabilization of a cleavage complex<ref>PMID: 21778401</ref>. The interplay between the <scene name='Sandbox_Reserved_390/Top/6'>protein</scene>, the <scene name='Sandbox_Reserved_390/Top/5'>DNA</scene>, and the drug explains the structure-activity relations of etoposide derivatives and the molecular basis of drug-resistant mutations. Also, at the <scene name='Sandbox_Reserved_390/Top/1'>active site</scene> we can see how the <scene name='Sandbox_Reserved_390/Top/7'>ligand</scene>, the <scene name='Sandbox_Reserved_390/Top/3'>alpha helices</scene>, and the <scene name='Sandbox_Reserved_390/Top/2'>beta sheets</scene> interact.

Crystal structure of a large fragment of human type II topoisomerases (TOP2) complexed to DNA and to the anticancer drug etoposide to reveal structural details of drug-induced stabilization of a cleavage complex<ref>PMID: 21778401</ref>.

The interplay between the <scene name='Sandbox_Reserved_390/Top/6'>protein</scene>, the <scene name='Sandbox_Reserved_390/Top/5'>DNA</scene>, and the drug explains the structure-activity relations of etoposide derivatives and the molecular basis of drug-resistant mutations.

Also, at the <scene name='Sandbox_Reserved_390/Top/1'>active site</scene> we can see how the <scene name='Sandbox_Reserved_390/Top/7'>ligand</scene>, the <scene name='Sandbox_Reserved_390/Top/3'>alpha helices</scene>, and the <scene name='Sandbox_Reserved_390/Top/2'>beta sheets</scene> interact.

==References==

Sandbox Reserved 390: Difference between revisions

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 === '''Human topoisomerase IIbeta in complex with DNA and etoposide''' ===
-<Structure load='3qx3' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /><!-- PLEASE DO NOT DELETE THIS TEMPLATE -->
+<Structure load='3qx3' size='600' frame='true' align='left' caption='Insert caption here' scene='Insert optional scene name here' /><!-- PLEASE DO NOT DELETE THIS TEMPLATE -->
-Crystal structure of a large fragment of human type II topoisomerases (TOP2) complexed to DNA and to the anticancer drug etoposide to reveal structural details of drug-induced stabilization of a cleavage complex<ref>PMID: 21778401</ref>. The interplay between the <scene name='Sandbox_Reserved_390/Top/6'>protein</scene>, the <scene name='Sandbox_Reserved_390/Top/5'>DNA</scene>, and the drug explains the structure-activity relations of etoposide derivatives and the molecular basis of drug-resistant mutations. Also, at the <scene name='Sandbox_Reserved_390/Top/1'>active site</scene> we can see how the <scene name='Sandbox_Reserved_390/Top/7'>ligand</scene>, the <scene name='Sandbox_Reserved_390/Top/3'>alpha helices</scene>, and the <scene name='Sandbox_Reserved_390/Top/2'>beta sheets</scene> interact.
+Crystal structure of a large fragment of human type II topoisomerases (TOP2) complexed to DNA and to the anticancer drug etoposide to reveal structural details of drug-induced stabilization of a cleavage complex<ref>PMID: 21778401</ref>.
+The interplay between the <scene name='Sandbox_Reserved_390/Top/6'>protein</scene>, the <scene name='Sandbox_Reserved_390/Top/5'>DNA</scene>, and the drug explains the structure-activity relations of etoposide derivatives and the molecular basis of drug-resistant mutations.
+Also, at the <scene name='Sandbox_Reserved_390/Top/1'>active site</scene> we can see how the <scene name='Sandbox_Reserved_390/Top/7'>ligand</scene>, the <scene name='Sandbox_Reserved_390/Top/3'>alpha helices</scene>, and the <scene name='Sandbox_Reserved_390/Top/2'>beta sheets</scene> interact.
 <!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
 ==References==
 <references />